Electrochemical phosphorylation: Green transformations for the synthesis of organophosphorus compounds in biology, agrochemicals, and drug design

Abstract

The topic of organophosphorus chemistry is vast and has numerous applications in biology, agrochemicals, and organic and drug design research. Complete conversions require the use of dangerous, moisture-sensitive phosphorylation agents in addition to oxidants, catalysts, high temperatures, and adverse conditions. Traditional methods have been widely applied to obtain phosphorylated substances. Recent developments in electricity-powered phosphorylation processes have led to the formation of more environmentally friendly synthetic reactions. Under mild conditions, these processes might continue with great atom economies. Our study primarily focused on the electrochemical phosphorylation processes that form specific bonds, including C(sp³)-P, C(sp²)-P, O-P, N-P, S-P, and Se-P. This article provides an overview of recent developments in electrochemical processes for the synthesis of organophosphorus-containing compounds.