Composite chronic lymphocytic leukemia and mantle cell lymphoma involving the bone marrow: a case report and literature review.

IF 3 Q3 PATHOLOGY

Journal of Pathology and Translational Medicine Pub Date : 2025-09-01 Epub Date: 2025-09-08 DOI:10.4132/jptm.2025.07.02

Roksolana Demianets, Susan O'Brien, Khosrow Mahdavi, Chenchen Niu, Sumayya Aslam, Truc Tran, Ying Zhang, Ashley Gamayo, Xiaohui Zhao, Sherif A Rezk

引用次数: 0

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a clinically indolent lymphoproliferative disorder characterized by accumulation of mature B-cell lymphocytes. Given the common CD5 co-expression, mantle cell lymphoma (MCL) is one of the most important entities in the differential diagnosis. MCL and CLL/SLL might exhibit overlapping morphologic and immunohistochemical features, making diagnosis particularly difficult in cases of composite lymphomas. Here, we present a unique case of composite lymphoma in an 86-year-old male, along with a literature review on the immunophenotypic variability of both MCL and CLL, which should always be confirmed with additional ancillary cytogenetic and molecular studies.

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累及骨髓的慢性淋巴细胞白血病和套细胞淋巴瘤1例报告并文献复习。

慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）是一种以成熟b细胞淋巴细胞积累为特征的临床惰性淋巴细胞增生性疾病。鉴于常见的CD5共表达，套细胞淋巴瘤（MCL）是鉴别诊断中最重要的实体之一。MCL和CLL/SLL可能表现出重叠的形态学和免疫组织化学特征，使得复合淋巴瘤的诊断特别困难。在这里，我们报告了一位86岁男性的独特复合性淋巴瘤病例，并对MCL和CLL的免疫表型变异性进行了文献回顾，这应该通过额外的辅助细胞遗传学和分子研究来证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pathology and Translational Medicine PATHOLOGY-

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

14 weeks

期刊介绍： The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.