Regioselective C-9 Arylation of Evodiamine via Bromination and Suzuki Coupling

IF 2 3区化学 Q2 CHEMISTRY, ORGANIC

Journal of Heterocyclic Chemistry Pub Date : 2025-07-14 DOI:10.1002/jhet.70029

Hongzhuo Wei, Xianheng Wang, Yuhe Wang, Changkuo Zhao

引用次数: 0

Abstract

A series of 9-aryl evodiamine derivatives were successfully synthesized in moderate yields via a two-step, regioselective process involving 9-bromination with Br₂ followed by Suzuki coupling with various arylboronic acids. The structures of the compounds were confirmed by ¹H NMR, ¹³C NMR, and HRMS analysis.

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通过溴化和Suzuki偶联的区域选择性C-9芳基化

通过与Br2的9-溴化反应以及与各种芳基硼酸的铃木偶联反应，成功地以中等产率合成了一系列9-芳基evolodiamine衍生物。化合物的结构经1H NMR、13C NMR和HRMS分析证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Heterocyclic Chemistry 化学-有机化学

CiteScore

5.20

自引率

4.20%

发文量

177

审稿时长

3.9 months

期刊介绍： The Journal of Heterocyclic Chemistry is interested in publishing research on all aspects of heterocyclic chemistry, especially development and application of efficient synthetic methodologies and strategies for the synthesis of various heterocyclic compounds. In addition, Journal of Heterocyclic Chemistry promotes research in other areas that contribute to heterocyclic synthesis/application, such as synthesis design, reaction techniques, flow chemistry and continuous processing, multiphase catalysis, green chemistry, catalyst immobilization and recycling.