Recent Advances in 11C-Labeling With [11C]CO2 for PET Imaging

IF 0.9 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Tianshuai Zhu, Jing-Jing Zhang, Lijun Tang, Zhen Chen
{"title":"Recent Advances in 11C-Labeling With [11C]CO2 for PET Imaging","authors":"Tianshuai Zhu,&nbsp;Jing-Jing Zhang,&nbsp;Lijun Tang,&nbsp;Zhen Chen","doi":"10.1002/jlcr.4162","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Carbon-11 (<sup>11</sup>C)-labeled radiotracers are invaluable tools in positron emission tomography (PET), enabling real-time visualization of biochemical processes with high sensitivity and specificity. Among the various <sup>11</sup>C synthons, cyclotron-produced [<sup>11</sup>C]CO<sub>2</sub> is a fundamental precursor, though its direct incorporation into complex molecules has traditionally been limited by its low reactivity, gaseous form, and short half-life. Recent advances in [<sup>11</sup>C]CO<sub>2</sub> fixation chemistry through both nonphotocatalytic and photocatalytic methods have significantly expanded its utility in the synthesis of structurally diverse compounds, including carboxylic acids, carbonates, carbamates, amides, and ureas. This review summarizes key developments in [<sup>11</sup>C]CO<sub>2</sub> radiolabeling strategies, with critical evaluation of substrate scope, radiochemical yield, molar activity, and clinical translation potential. These advances collectively expand the synthetic versatility of [<sup>11</sup>C]CO<sub>2</sub> and pave the way for the development of structurally diverse and clinically translatable PET imaging agents.</p>\n </div>","PeriodicalId":16288,"journal":{"name":"Journal of labelled compounds & radiopharmaceuticals","volume":"68 11-12","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of labelled compounds & radiopharmaceuticals","FirstCategoryId":"3","ListUrlMain":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jlcr.4162","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

Abstract

Carbon-11 (11C)-labeled radiotracers are invaluable tools in positron emission tomography (PET), enabling real-time visualization of biochemical processes with high sensitivity and specificity. Among the various 11C synthons, cyclotron-produced [11C]CO2 is a fundamental precursor, though its direct incorporation into complex molecules has traditionally been limited by its low reactivity, gaseous form, and short half-life. Recent advances in [11C]CO2 fixation chemistry through both nonphotocatalytic and photocatalytic methods have significantly expanded its utility in the synthesis of structurally diverse compounds, including carboxylic acids, carbonates, carbamates, amides, and ureas. This review summarizes key developments in [11C]CO2 radiolabeling strategies, with critical evaluation of substrate scope, radiochemical yield, molar activity, and clinical translation potential. These advances collectively expand the synthetic versatility of [11C]CO2 and pave the way for the development of structurally diverse and clinically translatable PET imaging agents.

Abstract Image

Abstract Image

Abstract Image

Abstract Image

[11C]CO2在PET成像中的11C标记研究进展
碳-11 (11C)标记的放射性示踪剂是正电子发射断层扫描(PET)的宝贵工具,能够以高灵敏度和特异性实时可视化生化过程。在各种11C合成子中,回旋产生的[11C]CO2是一种基本的前体,尽管其直接并入复杂分子传统上受到其低反应性、气态和半衰期短的限制。通过非光催化和光催化方法,[11C]CO2固定化学的最新进展显著扩展了其在合成结构多样的化合物方面的应用,包括羧酸、碳酸盐、氨基甲酸酯、酰胺和脲类。本文综述了[11C]CO2放射性标记策略的关键进展,并对底物范围、放射化学产率、摩尔活性和临床转化潜力进行了关键评估。这些进步共同扩大了[11C]CO2合成的多功能性,并为开发结构多样化和临床可翻译的PET显像剂铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.30
自引率
0.00%
发文量
57
审稿时长
1 months
期刊介绍: The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo. The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信