Multimaterial Shape Memory Polymer Fibers for Advanced Drug Release Applications

IF 21.3 1区工程技术 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Advanced Fiber Materials Pub Date : 2025-06-18 DOI:10.1007/s42765-025-00571-4

Xue Wan, Siyao Chen, Jingqi Ma, Chaoqun Dong, Hritwick Banerjee, Stella Laperrousaz, Pierre-Luc Piveteau, Yan Meng, Jinsong Leng, Fabien Sorin

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引用次数: 0

Abstract

Stimuli-responsive polymers offer unprecedented control over drug release in implantable delivery systems. Shape memory polymer fibers (SMPFs), with their large specific surface area and programmable properties, present promising alternatives for triggerable drug delivery. However, the existing SMPFs face limitations in resolution, architecture, scalability, and functionality. We introduce thermal drawing as a materials and processing platform to fabricate microstructured, multimaterial SMPFs that are tens of meters long, with high resolution (10 μm) and extreme aspect ratios (> 10⁵). These novel fibers achieve highly controlled, sequential drug release over tailored time periods of 6 months. Post thermal drawing photothermal coatings enable accelerated, spatially precise drug release within 4 months and facilitate light-triggered, untethered shape recovery. The fibers’ fast self-tightening capability within 40 s shows their potential as smart sutures for minimally invasive procedures that deliver drugs simultaneously. In addition, the advanced multimaterial platform facilitates the integration of optical and metallic elements within SMP systems, allowing highly integrated fibers with shape memory attributes and unprecedented functionalities. This versatile technology opens new avenues for diverse biomedical applications, including implantable drug delivery systems, smart sutures, wound dressings, stents, and functional textiles. It represents a significant advancement in precise spatio-temporal control of drug delivery and adaptive medical devices.

Graphical Abstract

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用于高级药物释放的多材料形状记忆聚合物纤维

刺激响应聚合物提供了前所未有的控制药物释放在植入式输送系统。形状记忆聚合物纤维（smpf）具有较大的比表面积和可编程特性，为触发药物输送提供了有希望的替代方案。然而，现有的smpf在分辨率、体系结构、可伸缩性和功能方面面临限制。我们引入热拉伸作为材料和加工平台来制造数十米长的微结构多材料smpf，具有高分辨率（10 μm）和极端宽高比（> 105）。这些新型纤维在6个月的特定时间内实现高度控制的顺序药物释放。热拉伸后的光热涂层可以在4个月内加速、精确地释放药物，并促进光触发、不受束缚的形状恢复。纤维在40秒内的快速自紧能力显示了它们作为同时输送药物的微创手术的智能缝合线的潜力。此外，先进的多材料平台促进了SMP系统中光学和金属元件的集成，使高度集成的光纤具有形状记忆属性和前所未有的功能。这种多功能技术为各种生物医学应用开辟了新的途径，包括植入式药物输送系统、智能缝合线、伤口敷料、支架和功能性纺织品。它代表了在药物输送和自适应医疗设备的精确时空控制方面的重大进步。图形抽象

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来源期刊

Advanced Fiber Materials Multiple-

CiteScore

18.70

自引率

11.20%

发文量

109

期刊介绍： Advanced Fiber Materials is a hybrid, peer-reviewed, international and interdisciplinary research journal which aims to publish the most important papers in fibers and fiber-related devices as well as their applications.Indexed by SCIE, EI, Scopus et al. Publishing on fiber or fiber-related materials, technology, engineering and application.