S07-02 Results from a new in vivo DNT study on glyphosate alone and in mixtures with other herbicides

Abstract

The potential neurodevelopmental toxicity of glyphosate remains a subject of debate within the research community. A recent study was conducted with the objective of investigating the impact of long-term effects of exposure to environmentally relevant levels of glyphosate and to its mixture with 2,4-D and dicamba during the intrauterine life (from gestational day 6) followed by the lactation period and 3 months after lactation, in a murine model. The results of the study indicated that exposure to glyphosate at very low doses led to a decline in research activity and an increase in anxiety, which was associated with an increase in degenerating cells and vacuolization in the hippocampus and cerebral cortex. In the mixture group, the effects were analogous, demonstrating an additive effect of the herbicides. It is important to note that chemical interactions, which often deviate from simple dose addition, have a major impact on neurotoxicity.