CEC04-02 How to rate essential information from analytics on test material

IF 2.9 3区医学 Q2 TOXICOLOGY

Toxicology letters Pub Date : 2025-09-01 DOI:10.1016/j.toxlet.2025.07.026

T. Schupp

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Abstract

Toxikokinetic studies aim at the characterization and quantitative description of the absorption, distribution, metabolism and elimination of the substance of interest. Reliable results are based on unequivocal identification of the target compound and its transformation products in biological samples, such as blood/plasma/serum, urine, bile, and faeces enabling scientifically sound interpretation of the data.

Several aspects will be highlighted: the importance of substance descriptions and its purity, including possible influences of impurities on test compound and analytical standards; the suitability and validation of analytical methods with regards to specificity, limits of detection and quantification and recovery.

Special consideration applies for the description of analytical methods in publications.

How work-up procedure can influence an analytical result will be exemplified against aromatic amines and isocyanates. Finally, it will be discussed how use can be made of older publications taking into account that at the time of the publication todays analytical methods were not available.

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如何评价测试材料分析的重要信息

毒代谢动力学研究的目的是表征和定量描述感兴趣的物质的吸收、分布、代谢和消除。可靠的结果基于对目标化合物及其在生物样品（如血液/血浆/血清、尿液、胆汁和粪便）中的转化产物的明确鉴定，从而能够对数据进行科学合理的解释。将强调几个方面：物质描述及其纯度的重要性，包括杂质对测试化合物和分析标准的可能影响；分析方法在特异性、检测限、定量限和回收率方面的适用性和有效性。出版物中对分析方法的描述应特别考虑。对于芳香胺和异氰酸酯，将举例说明后处理程序如何影响分析结果。最后，将讨论如何利用旧出版物，考虑到在今天出版时还没有可用的分析方法。

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