S03-03 Tools and approaches for the risk assessment of plant-derived substances of concern in food – the EFSA's perspective

IF 2.9 3区医学 Q2 TOXICOLOGY

Toxicology letters Pub Date : 2025-09-01 DOI:10.1016/j.toxlet.2025.07.052

E. Kouloura, A. Nathanail, B. Bottex, P. Manini, C. Eskes, M.B. Gilsenan, D. Maurici, C. Roncancio-Pena

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Abstract

Botanicals and botanical preparations are widely present in the European market as food, or ingredients of food supplements, or food/feed additives. Plants contain substances that are beneficial for human nutrition, however, a number of plant-derived substances can exert toxicological effects and thus pose potential health risks to consumers. The risk assessment of these substances is a complex procedure that requires a comprehensive approach to evaluate their inherent toxicity, exposure and potential adverse effects for human health.

EFSA is assessing hazards and risks of botanicals and plant-derived substances under different regulatory frameworks. By characterising the potential risks associated with substances of concern in plants, the risk assessments inform regulatory decisions (e.g. in the area of contaminants, maximum levels in food/feed) and are used for the evaluation of the safety of regulated products (e.g. novel food, food and feed additives).

As an overarching activity, EFSA has developed a toolkit to help assess the safety of botanicals and derived preparations intended for use as food, food supplements, or food/feed additives. Specifically, the development of the EFSA Compendium of Botanicals, an open-source hazard database, which is used to facilitate the hazard identification of plant-derived substances of potential concern.

This presentation will provide an overview with examples of the tools and approaches used by EFSA for the hazard identification and risk assessment of plant-derived substances of concern.

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食品中植物源性物质风险评估的工具和方法——欧洲食品安全局的观点

植物药和植物制剂作为食品、食品补充剂成分或食品/饲料添加剂广泛存在于欧洲市场。植物含有有益于人类营养的物质，然而，一些植物来源的物质可能产生毒理学效应，从而对消费者构成潜在的健康风险。这些物质的风险评估是一项复杂的程序，需要采用综合方法来评估其固有毒性、接触和对人类健康的潜在不利影响。欧洲食品安全局正在评估不同监管框架下植物药和植物衍生物质的危害和风险。通过描述与植物中关注物质相关的潜在风险，风险评估为监管决策提供信息（例如，在污染物领域，食品/饲料中的最高水平），并用于评估受监管产品的安全性（例如，新型食品，食品和饲料添加剂）。作为一项总体活动，欧洲食品安全局开发了一个工具包，以帮助评估用作食品、食品补充剂或食品/饲料添加剂的植物药和衍生制剂的安全性。具体来说，是开发欧洲食品安全局植物药纲要，这是一个开放源代码的危害数据库，用于促进潜在关注的植物源物质的危害识别。本报告将概述欧洲食品安全局用于危害识别和关注植物源物质风险评估的工具和方法的示例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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