S14-04 Integrate NAM data into bottom-up PBK modelling approaches

Abstract

Next generation risk assessment aims to reduce and ultimately replace animal testing while ensuring confidence in the approach. Recent results from ongoing projects such as ADME4NGRA and PARC will be shared to illustrate how in silico and in vitro NAM-based data can be implemented in PBK modelling. This integration is essential for the development of more reliable and ethical frameworks for chemical safety assessment.