CEC06-06 Gabapentinoids Misuse: Escalating Trends and Associated Risks

Abstract

As the opioid crisis continues to pose major public health issues, effective withdrawal syndrome and pain management strategies remain challenging but crucial. Gabapentinoids, initially developed as antiepileptic drugs, have become widely used to manage chronic pain, particularly neuropathic pain. Numerous studies highlight their safety and efficacy, whether used alone or in combination with opioids, to reduce opioid dosage, enhance the analgesic effects and reduce withdrawal symptoms. However, increasing prescription of gabapentinoids beyond approved indications has raised concerns. This expanded use has led to greater availability and, consequently, a rise in reports of gabapentinoid-related adverse events and poisonings, with a growing and alarming pattern of misuse and abuse. Such patterns are particularly prevalent among individuals with a history of opioid addiction, who seek to intensify their euphoric effects. One concern regarding gabapentinoid misuse is their possible drug-drug interaction with opioids and other central nervous system depressants. By enhancing the sedative and respiratory depressant effects, gabapentinoids contribute to a significantly higher risk of opioid-related overdose and death. These concerns highlight the need to reassess prescribing practices and raise awareness about the risks associated with gabapentinoid misuse, particularly in vulnerable populations.