Intelligent Chemical Synthesis in an Undergraduate Teaching Laboratory: Continuous Flow Synthesis of SNAr Reaction with Automated Robot-Assisted Condition Screening

IF 2.9 3区教育学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical Education Pub Date : 2025-08-15 DOI:10.1021/acs.jchemed.4c01072

Wenzhuo Xu, Haiyang Wang, Fujun Li, Leiyun Zhong, Wenbo Yang, Wenfeng Jiang, Shengyang Tao* and Lijing Zhang*,

引用次数: 0

Abstract

An integrated undergraduate teaching laboratory experiment was developed by applying an automated robot, a 48-well plate, and continuous flow chemistry in a typical S_NAr reaction. This experiment involved the concepts of green chemistry, homogeneous reaction, continuous flow chemistry and intelligent chemistry, encouraging students to determine the optimal flow synthesis conditions independently. By engaging in this experiment, students gain hands-on experience with modern chemical engineering practices and learn to appreciate the efficiency and sustainability of continuous flow processes.

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本科教学实验室的智能化学合成：自动化机器人辅助条件筛选SNAr反应的连续流合成

采用自动化机器人、48孔板、连续流动化学等方法，建立了典型SNAr反应的综合教学实验室实验。本实验涉及绿色化学、均相反应、连续流化学和智能化学的概念，鼓励学生自主确定最佳的流动合成条件。通过参与本实验，学生将获得现代化学工程实践的实践经验，并学会欣赏连续流程的效率和可持续性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chemical Education 化学-化学综合

CiteScore

5.60

自引率

50.00%

发文量

465

审稿时长

6.5 months

期刊介绍： The Journal of Chemical Education is the official journal of the Division of Chemical Education of the American Chemical Society, co-published with the American Chemical Society Publications Division. Launched in 1924, the Journal of Chemical Education is the world’s premier chemical education journal. The Journal publishes peer-reviewed articles and related information as a resource to those in the field of chemical education and to those institutions that serve them. JCE typically addresses chemical content, activities, laboratory experiments, instructional methods, and pedagogies. The Journal serves as a means of communication among people across the world who are interested in the teaching and learning of chemistry. This includes instructors of chemistry from middle school through graduate school, professional staff who support these teaching activities, as well as some scientists in commerce, industry, and government.