Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population.

IF 8.7 2区医学 Q1 CLINICAL NEUROLOGY

International Journal of Stroke Pub Date : 2025-09-05 DOI:10.1177/17474930251380170

Zhang Xia, Lingling Jiang, Xueli Cai, Jing Jing, Shan Li, Mengxing Wang, Suying Wang, Xuan Wang, Tiemin Wei, Yongjun Wang, Yuesong Pan, Yilong Wang

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引用次数: 0

Abstract

Background: Endothelial inflammation is involved in cerebral small vessel disease (CSVD) pathogenesis. Vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) are biomarkers of endothelial inflammation.

Aims: This study investigated the association of VCAM-1 and ICAM-1 with the presence of CSVD and CSVD burden.

Methods: This cross-sectional study included community residents from the Polyvascular Evaluation for Cognitive Impairment and Vascular Events (PRECISE) study. Fasting venous blood was drawn to assay VCAM-1 and ICAM-1. Cognition was assessed by the Montreal Cognitive Assessment (MoCA). Cognitive impairment was defined as MoCA scores < 26. White matter hyperintensity, lacunes, cerebral microbleeds, and enlarged perivascular spaces were evaluated in a 3.0T MRI scanner. CSVD burden was rated according to the criteria of Wardlaw's (score 0-4) and Rothwell's (score 0-6), and classified into four grades. Presence of CSVD was defined as CSVD burden score ⩾ 1.

Results: This study included 2596 participants with a mean age of 61.2 ± 6.7 years and 50.9% of males. Elevated VCAM-1 was associated with increased odds of presence of CSVD (Rothwell: odds ratio (OR) = 1.16, 95% confidence interval (CI): 1.06-1.26, P = 0.001), higher CSVD burden (Wardlaw: common OR (cOR) = 1.11, 95% CI: 1.02-1.21, P = 0.02; Rothwell: cOR = 1.16, 95% CI: 1.07-1.25, P < 0.001), and presence of cognition-impaired CSVD (Rothwell: OR = 1.15, 95% CI: 1.05-1.25, P = 0.003). VCAM-1 improved net reclassification index and integrated discrimination improvement for the presence of CSVD (Rothwell) and cognition-impaired CSVD (Rothwell). However, ICAM-1 was not associated with CSVD and did not improve prediction of CSVD.

Conclusion: Endothelial inflammation, especially VCAM-1, was associated with the presence of CSVD and higher CSVD burden.

查看原文本刊更多论文

社区人群中内皮炎症标志物与脑血管疾病之间的关系

背景：内皮炎症参与了脑血管病（CSVD）的发病机制。血管细胞粘附分子1 （VCAM-1）和细胞间粘附分子1 （ICAM-1）是内皮炎症的生物标志物。目的：本研究探讨VCAM-1和ICAM-1与CSVD和CSVD负担的关系。方法：这项横断面研究包括来自认知障碍和血管事件多血管评估（PRECISE）研究的社区居民。取空腹静脉血检测VCAM-1和ICAM-1。采用蒙特利尔认知评估（MoCA）评估认知能力。结果：本研究纳入2596名参与者，平均年龄61.2±6.7岁，男性占50.9%。升高的VCAM-1与CSVD存在几率增加（Rothwell: OR=1.16, 95%CI: 1.06-1.26， P=0.001）、CSVD负担加重（Wardlaw: OR=1.11, 95%CI: 1.02-1.21， P=0.02; Rothwell: cOR=1.16, 95%CI: 1.07-1.25， P）相关。结论：内皮炎症，尤其是VCAM-1，与CSVD存在和CSVD负担加重相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Stroke 医学-外周血管病

CiteScore

13.90

自引率

6.00%

发文量

132

审稿时长

6-12 weeks

期刊介绍： The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.