C2 dorsal root ganglion: the central hub for cervicogenic headache.

IF 2.1

Current opinion in anaesthesiology Pub Date : 2025-10-01 Epub Date: 2025-08-26 DOI:10.1097/ACO.0000000000001564

Samer Narouze

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Abstract

Purpose of review: The purpose of this review is to provide an update on the mechanisms of cervicogenic headache and the role of the C2 dorsal root ganglion (DRG) as a central hub for cervicogenic headache.

Recent findings: The suboccipital muscles have been implicated in the pathogenesis of cervicogenic headaches due to their connections with the dura mater. The myodural bridge (MDB) connects the suboccipital musculature to the spinal dura mater as it passed through the posterior atlanto-occipital and the atlanto-axial interspaces. The C1-C3 spinal nerves, the suboccipital muscles, and their MDBs are now well-recognized sources of cervicogenic headache.

Summary: We propose the C2 DRG as the central hub in cervicogenic headache. Because the C2 DRG receives afferent input from both C1 and C2, its blockade may disrupt sensory transmission from C1 to C3, the primary contributors to cervicogenic headache. Blocking the C2 DRG and the MDBs deep to the obliquus capitis inferior muscle can be highly effective in both the diagnosis and management of cervicogenic headache.

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C2背根神经节：颈源性头痛的中枢。

综述目的：本综述的目的是提供颈源性头痛的机制和C2背根神经节（DRG）作为颈源性头痛的中心枢纽的作用的最新进展。最近的研究发现：枕下肌肉与硬脑膜的连接与颈源性头痛的发病机制有关。硬膜肌桥（MDB）通过寰枕后间隙和寰枢间隙连接枕下肌肉和脊膜。C1-C3脊神经、枕下肌及其MDBs是目前公认的颈源性头痛的来源。总结：我们认为C2 DRG是颈源性头痛的中心枢纽。由于C2 DRG同时接受来自C1和C2的传入输入，其阻断可能会破坏C1到C3的感觉传递，这是颈源性头痛的主要原因。阻断C2 DRG和MDBs深至头斜下肌，对颈源性头痛的诊断和治疗都是非常有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current opinion in anaesthesiology

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