Alternate functions of physiological anticoagulants.

IF 5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2025-09-02 DOI:10.1016/j.jtha.2025.08.014

Teagan Prouse, Alan E Mast, Vera Ignjatovic, Mirjana Kovac, Zsuzsanna Bereczky, Rinku Majumder

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引用次数: 0

Abstract

The anticoagulant proteins antithrombin, protein C, protein S, and tissue factor pathway inhibitor are physiological regulators of the blood coagulation pathway and have complex roles in causing or modifying the severity of bleeding and clotting disorders. The anticoagulant activity, as well as alternative physiological functions, of these proteins also impact many other diseases beyond bleeding and clotting disorders. We searched PubMed for articles published between 2018 and early 2025 that pertained to alternative functions of these physiological anticoagulants in clinical disease and selected therapeutic applications in the following categories: cancer, cardiovascular disease, novel therapeutics, pregnancy health, inflammation and infection, blood-brain barrier protection, stroke, novel developments in thrombosis, and endothelial and platelet interactions. This review highlights recently identified physiological implications of antithrombin, protein C, protein S, and tissue factor pathway inhibitor functions that present an exciting therapeutic avenue for a diverse array of human diseases.

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生理性抗凝剂的替代功能。

抗凝血蛋白抗凝血酶（AT）、蛋白C （PC）、蛋白S （PS）和组织因子途径抑制剂（TFPI）是血液凝固途径的生理调节剂，在引起或改变出血和凝血障碍的严重程度方面具有复杂的作用。这些蛋白质的抗凝血活性以及其他生理功能也影响着除出血和凝血障碍之外的许多其他疾病。我们在PubMed检索了2018年至2025年初之间发表的有关这些生理抗凝剂在临床疾病中的替代功能的文章，并在以下类别中选择了治疗应用：癌症、心血管疾病、新疗法、妊娠健康、炎症和感染、血脑屏障保护、中风、血栓形成的新进展以及内皮和血小板相互作用。这篇综述强调了最近发现的AT、PC、PS和TFPI功能的生理意义，这些功能为多种人类疾病提供了令人兴奋的治疗途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.