Systematic review of reported outcomes for antegrade continence enema in patients with anorectal malformation and Hirschsprung disease

IF 2.5 2区医学 Q1 PEDIATRICS

Journal of pediatric surgery Pub Date : 2025-09-02 DOI:10.1016/j.jpedsurg.2025.162634

Signe Olsbø , Sara George Kiserud , Anders Telle Hoel , Kjetil Stensrud , Kristin Bjørnland

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引用次数: 0

Abstract

Aim

To identify reported parameters and study characteristics in the literature on antegrade continence enema (ACE) in patients with anorectal malformations (ARM) and Hirschsprung disease (HD).

Methods

Following PRISMA guidelines, we performed a search using the terms “anorectal malformation” or “Hirschsprung disease”, combined with “appendicostomy,” “antegrade continence enema,” “ACE”, “Malone”, or “cecostomy” in the databases Ovid MEDLINE, Cochrane Central, Embase, and CINAHL. Two reviewers independently screened and extracted data. Exclusion criteria included <10 patients with ARM and/or HD, age at ACE >18 years, non-English papers, opinion articles, conference abstracts, reviews, and meta-analyses.

Results

257 papers were identified, and 48 met the inclusion criteria. 76 % were retrospective studies and 9 % multi-center studies. Most studies (84 %) mixed three or more diagnoses, with a median of 16 ARM and 3 HD patients per study. A total of 301 different parameters were identified. Nine (3 %) parameters were mentioned in more than 50 % of the publications. The most frequent baseline parameters were sex (98 %) and age at surgery (88 %). Common outcome parameters included success of enema (92 %), complication rate (80 %) and revision surgery (79 %). Patient reported outcome measures were utilized in 12 (25 %) papers, and 3 (6 %) assessed quality of life.

Conclusion

There is substantial heterogeneity when reporting ACE outcomes. The use of validated questionnaires and PROMs is rare.

查看原文本刊更多论文

系统回顾对肛肠畸形和巨结肠疾病患者行顺行自制灌肠的报道结果。

目的：对肛肠畸形（ARM）和巨结肠病（HD）患者顺行性失禁灌肠（ACE）的文献报道参数和研究特点进行分析。方法：根据PRISMA指南，我们在Ovid MEDLINE、Cochrane Central、Embase和CINAHL数据库中使用术语“肛肠畸形”或“Hirschsprung病”，结合“阑尾造口术”、“顺行自制灌肠”、“ACE”、“Malone”或“结肠造口术”进行搜索。两名审稿人独立筛选和提取数据。排除标准包括18年、非英文论文、观点文章、会议摘要、综述和荟萃分析。结果：共纳入论文257篇，符合纳入标准48篇。76%为回顾性研究，9%为多中心研究。大多数研究（84%）混合了三种或更多的诊断，每项研究中位数为16例ARM和3例HD患者。总共确定了301个不同的参数。超过50%的出版物提到了9个（3%）参数。最常见的基线参数是性别（98%）和手术年龄（88%）。常见的结局参数包括灌肠成功率（92%）、并发症发生率（80%）和翻修手术（79%）。12篇（25%）论文使用了患者报告的结果测量方法，3篇（6%）论文评估了生活质量。结论：ACE结果报告存在很大的异质性。很少使用有效的问卷和prom。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of pediatric surgery 医学-外科

CiteScore

1.10

自引率

12.50%

发文量

569

审稿时长

38 days

期刊介绍： The journal presents original contributions as well as a complete international abstracts section and other special departments to provide the most current source of information and references in pediatric surgery. The journal is based on the need to improve the surgical care of infants and children, not only through advances in physiology, pathology and surgical techniques, but also by attention to the unique emotional and physical needs of the young patient.