Mesenchymal stem cells for lung diseases: focus on immunomodulatory action.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-09-05 DOI:10.1038/s41420-025-02303-4

Yuqian Feng, Jiamin Lu, Jing Jiang, Kezhan Shen, Kaibo Guo, Yazhen Zhong, Shengyou Lin

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Abstract

In recent years, the morbidity and mortality caused by acute and chronic lung diseases have gradually increased, becoming a global public health burden. However, modern medicine has yet to determine the exact treatment for lung diseases associated with inflammation. Alleviating lung diseases and repairing injured lung tissue are urgent issues that need to be resolved. Mesenchymal stem cells (MSCs) have been used to treat various inflammatory diseases owing to their powerful anti-inflammatory, anti-apoptotic, and tissue-regenerative properties. MSCs show great promise and have been shown to play a role in relieving lung diseases experimentally. The immune regulatory role of MSCs is thought to be a key mechanism underlying their multiple potential therapeutic effects. Immune cells and secreted factors contribute to tissue repair following lung injury. However, the overactivation of immune cells can aggravate lung injury. Here, we review evidence that MSCs act on immune cells to relieve lung diseases. Based on the immunomodulatory properties of MSCs, the specific mechanisms by which MSCs in alleviate lung diseases are reviewed, with a focus on innate and adaptive immunity. In addition, we discuss current challenges in the treatment of lung diseases using MSCs.

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间充质干细胞治疗肺部疾病：关注免疫调节作用。

近年来，急慢性肺部疾病的发病率和死亡率逐渐上升，成为全球公共卫生负担。然而，现代医学尚未确定与炎症相关的肺部疾病的确切治疗方法。缓解肺部疾病和修复受损肺组织是迫切需要解决的问题。间充质干细胞（MSCs）由于其强大的抗炎、抗凋亡和组织再生特性，已被用于治疗各种炎症性疾病。骨髓间充质干细胞在肺部疾病的治疗中显示出巨大的潜力。MSCs的免疫调节作用被认为是其多种潜在治疗作用的关键机制。免疫细胞和分泌因子有助于肺损伤后的组织修复。然而，免疫细胞的过度激活可加重肺损伤。在这里，我们回顾了MSCs作用于免疫细胞以缓解肺部疾病的证据。基于MSCs的免疫调节特性，本文综述了MSCs在缓解肺部疾病中的具体机制，重点介绍了先天免疫和适应性免疫。此外，我们还讨论了目前使用间充质干细胞治疗肺部疾病的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.