Unlocking the Potential of Polysaccharides for the Treatment of Lung Cancer.

IF 3 4区 医学 Q3 CHEMISTRY, MEDICINAL
Himanshu Singh, Rajnish Kumar, Avijit Mazumder
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引用次数: 0

Abstract

Background: Lung cancer remains a leading cause of cancer-related deaths worldwide, with its incidence continuing to rise. Despite advancements in clinical treatments, their effectiveness is often restricted, emphasizing the need for novel therapeutic strategies. Natural products have long been explored for drug development, and among them, polysaccharides have gained significant attention due to their biocompatibility, biodegradability, and multiple biological functions.

Methods: A comprehensive review examined contemporary research on the anticancer properties of natural polysaccharides, focusing specifically on their effects in lung cancer. The analysis included studies investigating their influence on cancer cell growth, immune system modulation, and therapeutic outcomes. Evidence from laboratory (in vitro), animal (in vivo), and clinical studies was evaluated to provide a comprehensive overview of their potential role in lung cancer management.

Results: Findings from recent studies indicate that polysaccharides can effectively inhibit the proliferation of lung cancer cells, thereby slowing tumor development. These compounds also appear to enhance immune responses by activating various immune cells and regulating cytokine production. Furthermore, polysaccharides have been shown to positively affect the gut microbiota, which may contribute to improved drug efficacy and a reduction in resistance to chemotherapy.

Discussion: The evidence suggests that natural polysaccharides exert multifaceted effects in the context of lung cancer treatment. Their ability to directly suppress tumor growth, modulate the immune system, and interact with the gut microbiome positions them as promising adjuncts to existing therapies. However, the precise molecular mechanisms underlying these effects are not yet fully understood, and variability in study designs warrants cautious interpretation of the results.

Conclusion: Natural polysaccharides represent a promising complementary approach for lung cancer therapy, given their potential to inhibit tumor progression, enhance immune function, and improve the effectiveness of conventional drugs. Continued research is essential to fully elucidate their mechanisms of action and to translate these findings into effective clinical interventions.

揭示多糖治疗肺癌的潜力。
背景:肺癌仍然是世界范围内癌症相关死亡的主要原因,其发病率持续上升。尽管临床治疗取得了进步,但其有效性往往受到限制,这强调了对新的治疗策略的需求。天然产物长期以来一直被探索用于药物开发,其中多糖因其生物相容性、生物可降解性和多种生物功能而备受关注。方法:全面回顾了天然多糖抗癌特性的当代研究,特别关注其在肺癌中的作用。分析包括研究它们对癌细胞生长、免疫系统调节和治疗结果的影响。我们对来自实验室(体外)、动物(体内)和临床研究的证据进行了评估,以全面概述它们在肺癌治疗中的潜在作用。结果:近年来的研究表明,多糖能有效抑制肺癌细胞的增殖,从而减缓肿瘤的发展。这些化合物似乎还通过激活各种免疫细胞和调节细胞因子的产生来增强免疫反应。此外,多糖已被证明对肠道微生物群有积极影响,这可能有助于提高药物疗效和减少对化疗的耐药性。讨论:有证据表明,天然多糖在肺癌治疗中发挥多方面的作用。它们能够直接抑制肿瘤生长,调节免疫系统,并与肠道微生物群相互作用,使它们成为现有疗法的有希望的辅助疗法。然而,这些效应背后的精确分子机制尚不完全清楚,研究设计的可变性要求对结果进行谨慎的解释。结论:天然多糖具有抑制肿瘤进展、增强免疫功能和提高常规药物疗效的作用,是一种很有前景的肺癌治疗补充方法。持续的研究对于充分阐明其作用机制并将这些发现转化为有效的临床干预措施至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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