Hypoxia Inducible Factor-1α Specific Probe for Tumor Hypoxia Positron Emission Tomography Imaging

IF 0.9 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2025-09-06 DOI:10.1002/jlcr.4163

Qian Chen, Teli Liu, Xiaoyi Guo, Qian Zhang, Siqi Hao, Yang Jiang, Xianteng Yang, Nan Li, Hua Zhu, Zhi Yang

引用次数: 0

Abstract

A peptide-based, hypoxia-inducible factor-1 α (HIF-1α) specific PET tracer for tumor hypoxia imaging is reported. It was prepared with a rapid Al¹⁸F labeling method with high stability. Al¹⁸F-CLLFVY specifically binds to HIF-1α with high affinity and shows higher uptake in cells under hypoxia. Al¹⁸F-CLLFVY demonstrated comparable tumor uptake to ¹⁸F-FMISO and better contrast.

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缺氧诱导因子-1α特异性探针用于肿瘤缺氧正电子发射断层成像

报道了一种基于肽的，缺氧诱导因子-1α (HIF-1α)特异性PET示踪剂用于肿瘤缺氧成像。采用快速Al18F标记法制备，稳定性高。Al18F-CLLFVY以高亲和力特异性结合HIF-1α，并在缺氧条件下的细胞中表现出更高的摄取。Al18F-CLLFVY表现出与18F-FMISO相当的肿瘤摄取和更好的对比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of labelled compounds & radiopharmaceuticals 医学-分析化学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo. The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.