{"title":"Cascade Aggregation Network for Accurate Polyp Segmentation","authors":"Yanru Jia, Yu Zeng, Huaping Guo","doi":"10.1049/syb2.70036","DOIUrl":null,"url":null,"abstract":"<p>Accurate polyp segmentation is crucial for computer-aided diagnosis and early detection of colorectal cancer. Whereas feature pyramid network (FPN) and its variants are widely used in polyp segmentation, inherent limitations existing in FPN include: (1) repeated upsampling degrades fine details, reducing small polyp segmentation accuracy and (2) naive feature fusion (e.g., summation) inadequately captures global context, limiting performance on complex structures. To address limitations, we propose a cascaded aggregation network (CANet) that systematically integrates multi-level features for refined representation. CANet adopts PVT transformer as the backbone to extract robust multi-level representations and introduces a cascade aggregation module (CAM) that enriches semantic features without sacrificing spatial details. CAM adopts a top-down enhancement pathway, where high-level features progressively guide the fusion of multiscale information, enhancing semantic representation while preserving spatial details. CANet further integrates a multiscale context-aware module (MCAM) and a residual-based fusion module (RFM). MCAM applies parallel convolutions with diverse kernel sizes and dilation rates to low-level features, enabling fine-grained multiscale extraction of local details and enhancing scene understanding. RFM fuses these local features with high-level semantics from CAM, enabling effective cross-level integration. Experiments show that CANet outperforms SOTA methods in in- and out-of-distribution tests.</p>","PeriodicalId":50379,"journal":{"name":"IET Systems Biology","volume":"19 1","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ietresearch.onlinelibrary.wiley.com/doi/epdf/10.1049/syb2.70036","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IET Systems Biology","FirstCategoryId":"99","ListUrlMain":"https://ietresearch.onlinelibrary.wiley.com/doi/10.1049/syb2.70036","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Accurate polyp segmentation is crucial for computer-aided diagnosis and early detection of colorectal cancer. Whereas feature pyramid network (FPN) and its variants are widely used in polyp segmentation, inherent limitations existing in FPN include: (1) repeated upsampling degrades fine details, reducing small polyp segmentation accuracy and (2) naive feature fusion (e.g., summation) inadequately captures global context, limiting performance on complex structures. To address limitations, we propose a cascaded aggregation network (CANet) that systematically integrates multi-level features for refined representation. CANet adopts PVT transformer as the backbone to extract robust multi-level representations and introduces a cascade aggregation module (CAM) that enriches semantic features without sacrificing spatial details. CAM adopts a top-down enhancement pathway, where high-level features progressively guide the fusion of multiscale information, enhancing semantic representation while preserving spatial details. CANet further integrates a multiscale context-aware module (MCAM) and a residual-based fusion module (RFM). MCAM applies parallel convolutions with diverse kernel sizes and dilation rates to low-level features, enabling fine-grained multiscale extraction of local details and enhancing scene understanding. RFM fuses these local features with high-level semantics from CAM, enabling effective cross-level integration. Experiments show that CANet outperforms SOTA methods in in- and out-of-distribution tests.
期刊介绍:
IET Systems Biology covers intra- and inter-cellular dynamics, using systems- and signal-oriented approaches. Papers that analyse genomic data in order to identify variables and basic relationships between them are considered if the results provide a basis for mathematical modelling and simulation of cellular dynamics. Manuscripts on molecular and cell biological studies are encouraged if the aim is a systems approach to dynamic interactions within and between cells.
The scope includes the following topics:
Genomics, transcriptomics, proteomics, metabolomics, cells, tissue and the physiome; molecular and cellular interaction, gene, cell and protein function; networks and pathways; metabolism and cell signalling; dynamics, regulation and control; systems, signals, and information; experimental data analysis; mathematical modelling, simulation and theoretical analysis; biological modelling, simulation, prediction and control; methodologies, databases, tools and algorithms for modelling and simulation; modelling, analysis and control of biological networks; synthetic biology and bioengineering based on systems biology.