Altered Cortical Gyrification, Functional Connections, and Underlying Neurotransmitter Information in Patients with Parkinson's Disease with Levodopa-Induced Dyskinesia.
IF 4.8
3区 医学
Q1 CLINICAL NEUROLOGY
引用次数: 0
Abstract
Introduction: The pathogenesis of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD) remains uncertain. Our work sought to examine the cortical gyrification pattern and its corresponding functional connectivity alterations, along with the underlying neurotransmitter information, in LID of PD.
Methods: We included 30 PD patients with LID (PD-LID group), 30 without LID (PD-NLID group), and 30 age- and gender-matched healthy controls (HC group). Regional cortical gyrification computed by local gyrification index (LGI) and seed-based resting-state functional connectivity (RSFC) were employed. We adopted the JuSpace toolset to further validate whether the spatial patterns in RSFC changes were linked with specific neurotransmitters.
Results: Compared to PD-NLID, PD-LID demonstrated lower regional LGI in the right inferior frontal gyrus (rIFG) (pars opercularis) and decreased RSFC between the rIFG and the left inferior parietal lobule (IPL). The decreased RSFC was correlated with the spatial distribution of the serotonin transporter (SERT) in the serotonergic system. In particular, the level of rIFG (pars opercularis) LGI was negatively related to the severity of LID and demonstrated good performance in detecting patients with PD-LID.
Conclusion: Our main findings indicated that the hypogyrification of rIFG and its corresponding functional connectivity reduction with left IPL, as well as the underlying serotonergic neurotransmitter distribution, could underlie the neurobiological underpinnings of LID.
左旋多巴诱导的帕金森病患者运动障碍的皮质回化、功能连接和潜在神经递质信息的改变
导读：帕金森病（PD）中左旋多巴诱导的运动障碍（LID）的发病机制尚不清楚。我们的工作旨在检查PD LID的皮质回旋模式及其相应的功能连接改变，以及潜在的神经递质信息。方法：我们纳入30例合并LID的PD患者（PD-LID组）、30例未合并LID的PD患者（PD- nlid组）和30例年龄和性别匹配的健康对照（HC组）。采用局部回转指数（local gyrification index， LGI）和基于种子的静息状态功能连接（resting-state functional connectivity， RSFC）计算区域皮质回转。我们采用JuSpace工具集进一步验证RSFC变化的空间模式是否与特定的神经递质有关。结果：与PD-NLID相比，PD-LID表现为右侧额下回（rIFG）（小叶）区域LGI降低，rIFG与左侧顶叶下小叶（IPL）之间的RSFC降低。RSFC的降低与血清素转运体（SERT）在血清素能系统中的空间分布有关。特别是，rIFG（包部）LGI水平与LID的严重程度呈负相关，在检测PD-LID患者方面表现良好。结论：我们的主要研究结果表明，rIFG的低水化及其相应的左IPL功能连通性降低，以及潜在的血清素能神经递质分布可能是LID的神经生物学基础。
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来源期刊
Neurology and Therapy
CLINICAL NEUROLOGY-
CiteScore
5.40
自引率
8.10%
发文量
103
审稿时长
6 weeks
期刊介绍：
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Neurology and Therapy aims to provide reliable and inclusive, rapid publication for all therapy related research for neurological indications, supporting the timely dissemination of research with a global reach, to help advance scientific discovery and support clinical practice.
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