Clinical characteristics and risk factors of metabolic dysfunction-associated steatotic liver disease in lean patients: results of the Polish Gallstone Surgery Registry.

IF 1.7 Q3 GASTROENTEROLOGY & HEPATOLOGY

Clinical and Experimental Hepatology Pub Date : 2025-06-01 Epub Date: 2025-06-09 DOI:10.5114/ceh.2025.151805

Iwona Gorczyca-Głowacka, Łukasz Nawacki, Magdalena Kołomańska, Robert Mazurkiewicz, Marcin Niżnik, Krzysztof Ratnicki, Małgorzata Czerniak, Piotr Myrcha, Maciej Bękarski, Joao Rocha-Neves, Juliana Pereira-Macedo, Kryspin Mitura, Laura Kacprzak, Małgorzata Pajer, Piotr Richter, Kamil Rapacz, Maciej Sroczyński, Mateusz Szmit, Stanisław Głuszek

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Abstract

Aim of the study: Data concerning the clinical manifestation and outcomes of lean metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce and inconsistent. The aim of the study was to evaluate the clinical characteristics of MASLD and predictors of its occurrence.

Material and methods: The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to the current criteria.

Results: Among 3,419 patients, MASLD was diagnosed in 24.2%. Lean MASLD was diagnosed in 11.3% of patients with MASLD. Independent predictors of lean MASLD were atherogenic dyslipidaemia (OR = 94.16, CI: 45.54-197.71, p < 0.0001), diabetes mellitus or prediabetes conditions (OR = 9.26, CI: 4.42-19.38, p < 0.0001) and hypertension (OR = 2.97, CI: 1.38-6.41, p = 0.0054).

Conclusions: Lean MASLD is not a rare form of the disease, and in the lean MASLD group there are patients with a high rate of metabolic abnormalities which may significantly increase cardiovascular risk and the risk of MASLD progression.

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瘦人患者代谢功能障碍相关脂肪变性肝病的临床特征和危险因素：波兰胆结石手术登记处的结果

研究目的：关于瘦代谢功能障碍相关脂肪变性肝病（MASLD）的临床表现和预后的数据很少且不一致。本研究的目的是评估MASLD的临床特征及其发生的预测因素。材料和方法：研究纳入了波兰胆结石手术登记处根据现行标准诊断为MASLD的患者。结果：3419例患者中，MASLD确诊率为24.2%。11.3%的MASLD患者被诊断为精益型MASLD。瘦MASLD的独立预测因子为动脉粥样硬化性血脂异常血症（OR = 94.16, CI: 45.54-197.71, p < 0.0001）、糖尿病或糖尿病前期状况（OR = 9.26, CI: 4.42-19.38, p < 0.0001）和高血压（OR = 2.97, CI: 1.38-6.41, p = 0.0054）。结论：瘦型MASLD并不是一种罕见的疾病，在瘦型MASLD组中，患者的代谢异常率很高，这可能会显著增加心血管风险和MASLD进展的风险。

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来源期刊

Clinical and Experimental Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

2.80

自引率

0.00%

发文量

期刊介绍： Clinical and Experimental Hepatology – quarterly of the Polish Association for Study of Liver – is a scientific and educational, peer-reviewed journal publishing original and review papers describing clinical and basic investigations in the field of hepatology.