Evolutionary diversification of ancestral genes across vertebrates and insects

IF 10.1 1区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Federica Mantica, Manuel Irimia
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引用次数: 0

Abstract

Vertebrates and insects diverged approximately 700 million years ago, and yet they retain a large core of conserved genes from their last common ancestor. These ancient genes present strong evolutionary constraints, which limit their overall sequence and expression divergence. However, these constraints can greatly vary across ancestral gene families and, in at least some cases, sequence and expression changes can have functional consequences. Importantly, overall patterns of sequence and expression divergence and their potential functional outcomes have never been explored in a genome-wide manner across large animal evolutionary distances. We focus on approximately 7000 highly conserved genes shared between vertebrates and insects, and we investigate global patterns of molecular diversification driven by changes in sequence and gene expression. We identify molecular features generally linked to higher or lower diversification rates, together with gene groups with similar diversification profiles in both clades. Moreover, we discover that specific sets of genes underwent differential diversification during vertebrate and insect evolution, potentially contributing to the emergence of unique phenotypes in each clade. We generate a comprehensive dataset of measures of sequence and expression divergence across vertebrates and insects, which reveals a continuous spectrum of evolutionary constraints among highly conserved genes. These constraints are normally consistent between these two clades and are associated with specific molecular features, but in some cases we also identify instances of lineage-specific diversification likely linked to functional evolution.
脊椎动物和昆虫祖先基因的进化多样化
脊椎动物和昆虫大约在7亿年前分化,但它们从最后的共同祖先那里保留了大量保守的基因。这些古老的基因表现出强烈的进化限制,这限制了它们的整体序列和表达差异。然而,这些限制可能在不同的祖先基因家族中有很大的不同,至少在某些情况下,序列和表达的变化可能会产生功能上的后果。重要的是,序列和表达差异的总体模式及其潜在的功能结果从未在大型动物进化距离的全基因组方式中进行过探索。我们关注脊椎动物和昆虫之间大约7000个高度保守的基因,并研究由序列和基因表达变化驱动的分子多样化的全球模式。我们确定了与较高或较低多样化率相关的分子特征,以及两个进化枝中具有相似多样化特征的基因群。此外,我们发现在脊椎动物和昆虫的进化过程中,特定的基因组经历了不同的多样化,这可能有助于在每个进化枝中出现独特的表型。我们生成了一个完整的数据集,测量脊椎动物和昆虫之间的序列和表达差异,揭示了高度保守基因之间的连续进化限制。这些限制在这两个分支之间通常是一致的,并且与特定的分子特征有关,但在某些情况下,我们也发现了谱系特异性多样化的实例,可能与功能进化有关。
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来源期刊
Genome Biology
Genome Biology Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
21.00
自引率
3.30%
发文量
241
审稿时长
2 months
期刊介绍: Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.
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