Lu Wu, Hong-Bin Liu, Xu-Wen Wang, Zi-Ning Tao, Ze-Peng Qu, Chao-Bi Lei, Yang-Yu Liu, Lei Dai
{"title":"Longitudinal profiling of the human gut microbiome reveals temporal and personalized responses to inulin.","authors":"Lu Wu, Hong-Bin Liu, Xu-Wen Wang, Zi-Ning Tao, Ze-Peng Qu, Chao-Bi Lei, Yang-Yu Liu, Lei Dai","doi":"10.1002/imo2.70029","DOIUrl":null,"url":null,"abstract":"<p><p>This study monitored gut microbiome changes in healthy volunteers following inulin intervention, revealing dynamic and highly individualized shifts in microbial composition and short-chain fatty acid production. Using <i>in vitro</i> batch cultures, correlation analysis, and predictive modeling, we explored the personalized microbiome response. Our findings highlight the individualized response of the gut microbiome to prebiotics and the need for precision nutrition.</p>","PeriodicalId":521007,"journal":{"name":"iMetaOmics","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379954/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"iMetaOmics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/imo2.70029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This study monitored gut microbiome changes in healthy volunteers following inulin intervention, revealing dynamic and highly individualized shifts in microbial composition and short-chain fatty acid production. Using in vitro batch cultures, correlation analysis, and predictive modeling, we explored the personalized microbiome response. Our findings highlight the individualized response of the gut microbiome to prebiotics and the need for precision nutrition.
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