Diagnostic performance of shear wave elastography and contrast-enhanced ultrasound in evaluating the pathological response of breast cancer patients to neoadjuvant chemotherapy: a meta-analysis.

IF 2.3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yan Liu, Wenxiao Li, Sirui Wang, Jinli Wang, Xiaowu Yuan, Yaqian Deng, Zelin Xu, Jixue Hou, Jun Li, Tao Song
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引用次数: 0

Abstract

Background: Neoadjuvant chemotherapy (NAC) is administered to specific subgroups of breast cancer patients to improve clinical outcomes. Achieving a pathological complete response (pCR) is strongly associated with improved survival. This meta-analysis systematically evaluated the diagnostic performance of shear wave elastography (SWE) and contrast-enhanced ultrasound (CEUS) in predicting the pathological response of breast cancer patients to NAC.

Methods: Relevant studies were searched in the databases of PubMed, Web of Science, and Embase until July 14, 2024. The articles were screened and relevant data were extracted, and study quality was assessed using Review Manager 5.4. The area under the curve (AUC) was calculated, and publication bias was evaluated by funnel plots generated using Stata 18.0. These analyses aimed to assess the diagnostic performance of SWE and CEUS in predicting the pathological response of breast cancer patients to NAC in terms of sensitivity (Sen) and specificity (Spe).

Results: A total of 22 studies comprising 1,725 breast cancer patients were included in the meta-analysis. The composite combined AUC, Sen, and Spe of CEUS in monitoring the pathological response of breast cancer patients to NAC were 0.86 [95% confidence interval (CI), 0.83-0.89], 0.88 (95% CI, 0.80-0.93), and 0.80 (95% CI, 0.74-0.84), respectively, and those of SWE were 0.88 (95% CI, 0.84-0.90), 0.82 (95% CI, 0.77-0.85), and 0.81 (95% CI, 0.74-0.86), respectively.

Conclusions: This meta-analysis confirmed that CEUS and SWE had comparable Spe in predicting the pathological response of breast cancer patients to NAC (CEUS: 0.80 vs. SWE: 0.81), but CEUS had superior Sen (0.88 vs. 0.82). Both modalities have clinically relevant diagnostic value (AUC >0.80), supporting their utility in the non-invasive monitoring of NAC efficacy.

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剪切波弹性成像和对比增强超声在评估乳腺癌患者对新辅助化疗病理反应中的诊断价值:一项荟萃分析。
背景:新辅助化疗(NAC)用于特定亚组乳腺癌患者以改善临床预后。实现病理完全缓解(pCR)与提高生存率密切相关。本荟萃分析系统地评估了剪切波弹性成像(SWE)和对比增强超声(CEUS)在预测乳腺癌患者对NAC的病理反应方面的诊断性能。方法:截至2024年7月14日,检索PubMed、Web of Science和Embase数据库的相关研究。筛选文章并提取相关数据,使用Review Manager 5.4评估研究质量。计算曲线下面积(AUC),并通过Stata 18.0生成的漏斗图评估发表偏倚。这些分析旨在评估SWE和CEUS在预测乳腺癌患者对NAC的病理反应方面的敏感性(Sen)和特异性(Spe)。结果:荟萃分析共纳入了22项研究,包括1725名乳腺癌患者。CEUS监测乳腺癌患者NAC病理反应的综合AUC、Sen、Spe分别为0.86[95%可信区间(CI), 0.83 ~ 0.89]、0.88 (95% CI, 0.80 ~ 0.93)、0.80 (95% CI, 0.74 ~ 0.84), SWE分别为0.88 (95% CI, 0.84 ~ 0.90)、0.82 (95% CI, 0.77 ~ 0.85)、0.81 (95% CI, 0.74 ~ 0.86)。结论:该荟萃分析证实,CEUS和SWE在预测乳腺癌患者对NAC的病理反应方面具有相当的Spe (CEUS: 0.80 vs. SWE: 0.81),但CEUS具有更高的Sen (0.88 vs. 0.82)。两种方法都具有临床相关的诊断价值(AUC >0.80),支持它们在无创监测NAC疗效方面的应用。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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