Disrupted neurovascular coupling in patients with lung cancer after chemotherapy.

IF 2.3 2区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Quantitative Imaging in Medicine and Surgery Pub Date : 2025-09-01 Epub Date: 2025-08-15 DOI:10.21037/qims-24-1321
Lanyue Hu, Shaohua Ding, Jun Yao, Yujie Zhang, Jia You, Huiyou Chen, Qian Li, Yu-Chen Chen, Xindao Yin
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引用次数: 0

Abstract

Background: Chemotherapy-related cognitive impairments (CRCIs) are frequently reported by patients with non-small cell lung cancer (NSCLC) following chemotherapy treatment. Studies have revealed that cognitive impairment may be linked to abnormal spontaneous neuronal activity and changes in cerebral blood flow (CBF). However, the specific impact of neurovascular coupling (NVC) alterations on patients who have undergone chemotherapy has not been clarified. The aim of this study was to examine the variations in NVC in patients with lung cancer postchemotherapy and to determine potential correlations between these NVC alterations and neurocognitive dysfunction.

Methods: A sample of 43 patients with NSCLC was recruited, including 20 patients treated with chemotherapy [CT(+)] and 23 chemotherapy-naïve [CT(-)] individuals who underwent pseudocontinuous arterial spin labeling (pCASL) scans and resting-state functional magnetic resonance imaging (rs-fMRI), along with neurocognitive evaluations. Global and regional NVC indices were assessed according to correlation coefficients and the ratios between CBF and neuronal activity-derived metrics, including the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo). Statistical analyses were conducted to calculate the difference between groups and characterize relationships between alterations in global and regional NVC and cognitive performance.

Results: In comparison to the CT(-) group, the CT(+) group exhibited significantly lower coupling strength for global CBF-ALFF and CBF-ReHo correlations (P<0.05). Regionally, the CT(+) group demonstrated a decreased CBF:ALFF ratio in the right middle temporal gyrus (MTG) and left middle frontal gyrus (MFG), as well as an increased CBF:ALFF ratio in the left thalamus and left parahippocampal region. Furthermore, the CT(+) group had higher CBF:ReHo ratios in the left precuneus, right central operculum, right inferior parietal lobule, and right superior occipital gyrus but lower CBF:ReHo ratios in the left inferior frontal gyrus and right MFG (false-discovery rate-corrected P value <0.05). Notably, there was a negative correlation observed between Montreal Cognitive Assessment scores and memory scores and the CBF:ALFF ratios in the right MFG and left parahippocampal region.

Conclusions: This research offers comprehensive insights into the neurological foundations of CRCI. The application of multimodal neuroimaging analyses combining rs-fMRI and pCASL may uncover the induction of neurovascular decoupling in lung cancer patients undergoing chemotherapy.

Abstract Image

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Abstract Image

肺癌患者化疗后神经血管偶联中断。
背景:化疗相关认知障碍(CRCIs)在非小细胞肺癌(NSCLC)患者化疗后经常被报道。研究表明,认知障碍可能与异常的自发神经元活动和脑血流量(CBF)的变化有关。然而,神经血管偶联(NVC)改变对化疗患者的具体影响尚未明确。本研究的目的是检查肺癌患者化疗后NVC的变化,并确定这些NVC改变与神经认知功能障碍之间的潜在相关性。方法:招募了43名NSCLC患者,包括20名接受化疗的患者[CT(+)]和23名chemotherapy-naïve [CT(-)]个体,他们接受了假连续动脉自旋标记(pCASL)扫描和静息状态功能磁共振成像(rs-fMRI),并进行了神经认知评估。根据CBF与神经元活动衍生指标(包括低频波动幅度(ALFF)和区域均匀性(ReHo))之间的相关系数和比率,评估全球和区域NVC指数。通过统计分析计算各组之间的差异,并描述整体和区域NVC变化与认知表现之间的关系。结果:与CT(-)组相比,CT(+)组整体CBF-ALFF和CBF-ReHo相关性的耦合强度明显较低(p结论:本研究为CRCI的神经学基础提供了全面的见解。应用rs-fMRI和pCASL相结合的多模态神经影像学分析可能揭示肺癌化疗患者神经血管解耦的诱导机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Quantitative Imaging in Medicine and Surgery
Quantitative Imaging in Medicine and Surgery Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
4.20
自引率
17.90%
发文量
252
期刊介绍: Information not localized
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