Meta-analysis of the association between gut microbiota and postpartum depression.

IF 2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Psychosomatic Obstetrics & Gynecology Pub Date : 2025-12-31 Epub Date: 2025-08-28 DOI:10.1080/0167482X.2025.2548567

Yan Guo, Wangxiang Chen

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引用次数: 0

Abstract

Objective: This study aimed to explore the association between gut microbiota and postpartum depression (PPD) through meta-analysis, providing a basis for effective clinical preventive interventions..

Methods: Systematic searches were conducted in English databases (Cochrane Library, Embase, Web of Science, PubMed) for studies published up to April 2025. Literature screening used a double-blind method, and quality assessment was performed with the AHRQ methodological tool evaluating 11 core dimensions. Meta-analysis was conducted using STATA 18.0 software on eligible studies.

Results: Twelve studies were included. α-Proteobacteria was a significant risk factor for PPD (OR = 1.19, 95%CI: 1.11-1.28, p < 0.05). Protective factors included Bifidobacterium (OR = 0.82), Ruminococcaceae (OR = 0.88), Prevotellaceae (OR = 0.89), Veillonellaceae (OR = 0.83), and Clostridia (OR = 0.84). Included studies showed low heterogeneity, with robust results and low publication bias risk.

Conclusion: PPD is closely linked to specific gut microbiota imbalances. α-Proteobacteria may increase PPD risk via inflammatory responses, while beneficial microbiota exert protective effects through neurotransmitter regulation, short-chain fatty acid metabolism, and gut-brain axis modulation. Gut microbiota could serve as a target for PPD intervention and prevention.

查看原文本刊更多论文

肠道菌群与产后抑郁关系的meta分析。

目的：通过荟萃分析，探讨肠道菌群与产后抑郁症（PPD）的关系，为制定有效的临床预防干预措施提供依据。方法：系统检索英文数据库（Cochrane Library, Embase, Web of Science, PubMed）中截至2025年4月发表的研究。文献筛选采用双盲方法，质量评估采用AHRQ方法工具评估11个核心维度。采用STATA 18.0软件对符合条件的研究进行meta分析。结果：纳入12项研究。α-变形菌群是PPD的重要危险因素（OR = 1.19, 95%CI: 1.11-1.28, p）。结论：PPD与特定肠道菌群失衡密切相关。α-变形菌群可能通过炎症反应增加PPD风险，而有益菌群通过调节神经递质、短链脂肪酸代谢和肠-脑轴调节发挥保护作用。肠道菌群可作为PPD干预和预防的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Psychosomatic Obstetrics & Gynecology 医学-妇产科学

CiteScore

6.10

自引率

3.20%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Psychosomatic Obstetrics and Gynecology was founded in 1982 in order to provide a scientific forum for obstetricians, gynecologists, psychiatrists and psychologists, academic health professionals as well as for all those who are interested in the psychosocial and psychosomatic aspects of women’s health. Another of its aims is to stimulate obstetricians and gynecologists to pay more attention to this very important facet of their profession.