Development of a blood-based lipidomic fat quality score for the risk of ischemic stroke.

IF 4.5 3区 医学 Q1 CLINICAL NEUROLOGY
Iolanda Lázaro, Leila Luján-Barroso, Natalia Soldevila-Domenech, Antonio J Amor, Emilio Ortega, Emilio Ros, Maria-José Sánchez, Miguel Rodríguez-Barranco, Maria Dolores Chirlaque, José Maria Huerta, Marcela Guevara, Conchi Moreno-Iribas, Catalina Bonet, Helmut Schröder, Montserrat Fitó, Nathan L Tintle, Nathan Ryder, William S Harris, Antonio Agudo, Aleix Sala-Vila
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引用次数: 0

Abstract

Introduction: Poor-quality diets promote ischemic stroke. Red blood cell fatty acids (RBC-FAs) are objective, long-term biomarkers of diet. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain, we developed a blood-based lipidomic fat quality (LFQ) score considering pre-defined RBC-FA diet-related biomarkers, and examined whether LFQ score relates to the risk of ischemic stroke.

Patients and methods: We determined the RBC-FAs (n = 438 cases of incident ischemic stroke, n = 438 matched controls). For each participant, we scored 1 for each beneficial metric (C15:0+C17:0; C18:2n-6; C18:3n-3; C20:5n-3; C22:6n-3) ⩾the median of the control group; and 1 for each detrimental metric (C16:0; C16:1n-7; C18:0) n = 2468 participants from the Framingham Offspring Study without ischemic stroke at baseline, 12-year median follow-up, n = 121 cases).

Results: In a fully adjusted model, the Odds Ratio (OR) for ischemic stroke was 0.86 (95% confidence interval [CI] = 0.77-0.95) for each 1-unit increase of the LFQ score. Compared to individuals at the lowest category of LFQ score (0-3 points), those at the top category (5-8 points) had lower odds (OR = 0.64, 95% CI = 0.44-0.94). The findings were similar in the Framingham Offspring Study (Hazard Ratio [HR] for each 1-unit increase = 0.83; 95% CI = 0.70-0.99; HR for those at top category = 0.49; 95% CI = 0.29-0.84, compared to those at the lowest category).

Conclusion: Low blood-based LFQ scores relate to a high risk of ischemic stroke.

缺血性脑卒中风险的基于血脂组学脂肪质量评分的发展。
导读:低质量的饮食会促进缺血性中风。红细胞脂肪酸(RBC-FAs)是客观的、长期的饮食生物标志物。在欧洲癌症和营养前瞻性调查(EPIC)-西班牙的一项病例对照研究中,我们开发了一种基于血液的脂质组学脂肪质量(LFQ)评分,考虑了预定义的RBC-FA饮食相关生物标志物,并检查了LFQ评分是否与缺血性卒中的风险相关。患者和方法:我们测定了红细胞fas (n = 438例缺血性卒中患者,n = 438例匹配对照)。对于每个参与者,我们为每个有益指标(C15:0+C17:0; C18:2n-6; C18:3n-3; C20:5n-3; C22:6n-3)的小于对照组的中位数得分为1;每项有害指标为1 (C16:0; C16:1n-7; C18:0),来自Framingham后代研究的2468名基线时无缺血性卒中的受试者,中位随访12年,n = 121例)。结果:在完全调整模型中,LFQ评分每增加1个单位,缺血性卒中的优势比(OR)为0.86(95%可信区间[CI] = 0.77-0.95)。与LFQ得分最低类别(0-3分)的个体相比,最高类别(5-8分)的个体的赔率较低(OR = 0.64, 95% CI = 0.44-0.94)。弗雷明汉后代研究的结果也类似(每增加1个单位的风险比[HR] = 0.83; 95% CI = 0.70-0.99;与最低类别相比,最高类别的风险比= 0.49;95% CI = 0.29-0.84)。结论:低血基LFQ评分与缺血性脑卒中的高风险相关。
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来源期刊
CiteScore
7.50
自引率
6.60%
发文量
102
期刊介绍: Launched in 2016 the European Stroke Journal (ESJ) is the official journal of the European Stroke Organisation (ESO), a professional non-profit organization with over 1,400 individual members, and affiliations to numerous related national and international societies. ESJ covers clinical stroke research from all fields, including clinical trials, epidemiology, primary and secondary prevention, diagnosis, acute and post-acute management, guidelines, translation of experimental findings into clinical practice, rehabilitation, organisation of stroke care, and societal impact. It is open to authors from all relevant medical and health professions. Article types include review articles, original research, protocols, guidelines, editorials and letters to the Editor. Through ESJ, authors and researchers have gained a new platform for the rapid and professional publication of peer reviewed scientific material of the highest standards; publication in ESJ is highly competitive. The journal and its editorial team has developed excellent cooperation with sister organisations such as the World Stroke Organisation and the International Journal of Stroke, and the American Heart Organization/American Stroke Association and the journal Stroke. ESJ is fully peer-reviewed and is a member of the Committee on Publication Ethics (COPE). Issues are published 4 times a year (March, June, September and December) and articles are published OnlineFirst prior to issue publication.
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