First Report of Long-term Outcomes of 700 Pediatric Liver Transplants From India.

IF 5 2区医学 Q1 IMMUNOLOGY

Transplantation Pub Date : 2025-09-03 DOI:10.1097/TP.0000000000005510

Naresh Shanmugam, Ashwin Rammohan, Jagadeesh Menon, Anu Vasudevan, Ravikumar Thambidurai, Rajesh Rajalingam, Kumar Palaniappan, Gomathy Narasimhan, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mohamed Rela

{"title":"First Report of Long-term Outcomes of 700 Pediatric Liver Transplants From India.","authors":"Naresh Shanmugam, Ashwin Rammohan, Jagadeesh Menon, Anu Vasudevan, Ravikumar Thambidurai, Rajesh Rajalingam, Kumar Palaniappan, Gomathy Narasimhan, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mohamed Rela","doi":"10.1097/TP.0000000000005510","DOIUrl":null,"url":null,"abstract":"Background: Acceptance of pediatric liver transplantation (PLT) in this part of the world has been slow because of a number of considerations, including those of cost, infections, and the nonavailability of expertise. Despite several obstacles, PLT has seen impressive growth in the recent years. Against a backdrop of this changing landscape of PLT in India, we present our experience of performing 700 PLT over a period of 13 y.Methods: All 700 children (<18 y old) who underwent PLT from January 2011 to February 2024 were included in the study. Children were grouped in to group 1 (<5 kg), group 2 (5-10 kg) and group 3 (>10 kg) and survival analysis was performed. The outcomes of PLT performed over the first 7 y were compared with those of the next 6 y, with the aim to present any learning curve/teething troubles that could have presented while setting up the unit.Results: The overall 90-d, 1-, 5-, and 10-y survivals were 94.2%, 90.4%, 86%, and 85.4%, respectively. The median (interquartile range) follow-up of the entire cohort was 65 mo (16-96 mo). There was no statistically significant difference in survival between the 3 weight-based groups or between the 2 eras.Conclusions: We present the first report of long-term survival of the largest series of PLT from an emerging nation. Remarkably, with increasing numbers of liver transplantation being performed in the region over the past decade, the focus of care has now shifted from achieving early survival after liver transplantation to long-term follow-up.","PeriodicalId":23316,"journal":{"name":"Transplantation","volume":" ","pages":""},"PeriodicalIF":5.0000,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transplantation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/TP.0000000000005510","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Acceptance of pediatric liver transplantation (PLT) in this part of the world has been slow because of a number of considerations, including those of cost, infections, and the nonavailability of expertise. Despite several obstacles, PLT has seen impressive growth in the recent years. Against a backdrop of this changing landscape of PLT in India, we present our experience of performing 700 PLT over a period of 13 y.

Methods: All 700 children (<18 y old) who underwent PLT from January 2011 to February 2024 were included in the study. Children were grouped in to group 1 (<5 kg), group 2 (5-10 kg) and group 3 (>10 kg) and survival analysis was performed. The outcomes of PLT performed over the first 7 y were compared with those of the next 6 y, with the aim to present any learning curve/teething troubles that could have presented while setting up the unit.

Results: The overall 90-d, 1-, 5-, and 10-y survivals were 94.2%, 90.4%, 86%, and 85.4%, respectively. The median (interquartile range) follow-up of the entire cohort was 65 mo (16-96 mo). There was no statistically significant difference in survival between the 3 weight-based groups or between the 2 eras.

Conclusions: We present the first report of long-term survival of the largest series of PLT from an emerging nation. Remarkably, with increasing numbers of liver transplantation being performed in the region over the past decade, the focus of care has now shifted from achieving early survival after liver transplantation to long-term follow-up.

查看原文本刊更多论文

印度700例小儿肝移植的长期疗效报告。

背景：由于一些考虑因素，包括费用、感染和缺乏专业知识，儿童肝移植（PLT）在世界这一地区的接受程度一直较慢。尽管存在一些障碍，PLT近年来取得了令人印象深刻的增长。在印度PLT不断变化的背景下，我们介绍了我们在13年时间内进行700例PLT的经验。方法：对所有700名儿童（10公斤）进行了生存分析。将前7年执行的PLT结果与接下来的6年进行比较，目的是呈现在设置单元时可能出现的任何学习曲线/初期问题。结果：90 d、1年、5年和10年的总存活率分别为94.2%、90.4%、86%和85.4%。整个队列的中位（四分位数范围）随访时间为65个月（16-96个月）。3个体重组之间或2个时代之间的生存率无统计学差异。结论：我们提出了来自新兴国家的最大系列PLT的长期生存的第一份报告。值得注意的是，在过去十年中，随着该地区肝移植数量的增加，护理的重点现已从实现肝移植后的早期生存转向长期随访。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.