Drugs associated with behavioral addictions: Real world analysis using the WHO pharmacovigilance database.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY

Therapie Pub Date : 2025-07-25 DOI:10.1016/j.therap.2025.07.002

Louis Asselin, Edouard-Jules Laforgue, Mélanie Duval, Bruno Revol, Gwenaëlle Veyrac, Marie Grall-Bronnec, Caroline Victorri-Vigneau

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引用次数: 0

Abstract

Objectives: Behavioral addictions (BA) are a newly recognized diagnostic entity. While some drugs are known to induce BA, some of them remains unknown. The aim of this study was to identify drugs for which B is not listed in the summaries of product characteristics.

Methods: We conducted a search on Vigibase to identify health professional's cases where drugs are "suspect" coded with the following preferred terms: (1) 'behavioral addiction', (2) 'gambling disorder', (3) 'gaming disorder', (4) 'compulsive sexual behavior', (5) 'bulimia nervosa', (6) 'binge eating' and (7) 'compulsive shopping'. We selected drugs "suspect" in at least five cases for which the summaries of product characteristics do not mention BA. We applied a downward descriptive process (drug only suspect, positive dechallenge, well-documented cases) together with a disproportionality analysis and a PubMed search.

Results: We identified 24 drugs across 7 pharmacological classes: antidepressants, antipsychotics, antiepileptics, benzodiazepines, psychostimulants, antidiabetics and retinoids. Olanzapine was the only accompanied by well-documented cases with positive dechallenges, exhibiting significant disproportionality analysis and associated with publications from the PubMed search.

Conclusion: Our results highlights that several drugs and notably olanzapine are associated with BA. Further research using definitions enabling the diagnosis of addictive disorders for various BA is warranted.

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与行为成瘾相关的药物：使用世卫组织药物警戒数据库的真实世界分析。

目的：行为成瘾（BA）是一种新认识的诊断实体。虽然已知一些药物可诱导BA，但其中一些药物仍然未知。本研究的目的是确定B未在产品特性摘要中列出的药物。方法：我们在Vigibase上进行搜索，以确定医疗专业人员使用以下首选术语编码的“可疑”药物案例：(1)“行为成瘾”，(2)“赌博障碍”，(3)“游戏障碍”，(4)“强迫性行为”，(5)“神经性贪食症”，(6)“暴食”和(7)“强迫性购物”。我们在至少5个案例中选择了“可疑”的药物，这些案例的产品特征总结中没有提到BA。我们采用了向下描述过程（仅怀疑药物，阳性挑战，有充分记录的病例），并进行了歧化分析和PubMed搜索。结果：我们确定了7类药物中的24种药物：抗抑郁药、抗精神病药、抗癫痫药、苯二氮卓类药物、精神兴奋剂、抗糖尿病药和类维生素a。奥氮平是唯一伴随阳性挑战的充分记录的病例，显示出显著的歧化分析，并与PubMed搜索的出版物相关。结论：我们的研究结果强调了几种药物，特别是奥氮平与BA有关。进一步的研究使用的定义能够诊断成瘾性障碍的各种BA是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapie 医学-药学

CiteScore

3.50

自引率

7.70%

发文量

132

审稿时长

57 days

期刊介绍： Thérapie is a peer-reviewed journal devoted to Clinical Pharmacology, Therapeutics, Pharmacokinetics, Pharmacovigilance, Addictovigilance, Social Pharmacology, Pharmacoepidemiology, Pharmacoeconomics and Evidence-Based-Medicine. Thérapie publishes in French or in English original articles, general reviews, letters to the editor reporting original findings, correspondence relating to articles or letters published in the Journal, short articles, editorials on up-to-date topics, Pharmacovigilance or Addictovigilance reports that follow the French "guidelines" concerning good practice in pharmacovigilance publications. The journal also publishes thematic issues on topical subject. The journal is indexed in the main international data bases and notably in: Biosis Previews/Biological Abstracts, Embase/Excerpta Medica, Medline/Index Medicus, Science Citation Index.