Mucus-derived biomaterial dressings: a novel approach to accelerate wound healing.

IF 13.3 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Theranostics Pub Date : 2025-07-24 eCollection Date: 2025-01-01 DOI:10.7150/thno.115988

Xuanqi Peng, Ziyi Wang, Leo Wang, Weiliang Hou

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引用次数: 0

Abstract

Wound management remains a clinical challenge due to the complexity of healing processes. Traditional dressings with passive protection mechanisms and modern synthetic alternatives often fail to recapitulate the dynamic biological interactions in the wound microenvironment. Mucus is a naturally widely available biomaterial, exhibiting superior bioactive properties as a viscoelastic gel-like substance. Notably, natural mucus derived from diverse biological sources has garnered significant attention as advanced wound dressings. This review explores the potential of natural mucus from animals, plants, microorganisms, and other complex sources as multifunctional wound healing platforms. By analyzing the therapeutic effects of natural mucus, we evaluate its key molecular mechanisms and performance metrics against clinical wound dressings. This establishes a scientific framework for mucus-inspired biomaterials design. The comprehensive assessment not only reveals the untapped potential of renewable biological resources in developing eco-friendly, high-performance wound care alternatives but also provides theoretical guidance for developing next-generation dressings with bioactive, self-adaptive, and environmentally responsive characteristics.

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黏液来源的生物材料敷料：一种加速伤口愈合的新方法。

由于愈合过程的复杂性，伤口管理仍然是一个临床挑战。具有被动保护机制的传统敷料和现代合成替代品往往无法再现伤口微环境中动态的生物相互作用。粘液是一种天然的广泛可用的生物材料，作为一种粘弹性凝胶状物质，具有优越的生物活性。值得注意的是，来自不同生物来源的天然粘液作为高级伤口敷料已经引起了极大的关注。这篇综述探讨了动物、植物、微生物和其他复杂来源的天然粘液作为多功能伤口愈合平台的潜力。通过分析天然黏液的治疗效果，我们评估了其对临床伤口敷料的关键分子机制和性能指标。这为以黏液为灵感的生物材料设计建立了一个科学框架。这项综合评估不仅揭示了可再生生物资源在开发环保、高性能伤口护理替代品方面尚未开发的潜力，而且为开发具有生物活性、自适应和环境响应特性的下一代敷料提供了理论指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

25.40

自引率

1.60%

发文量

433

审稿时长

1 months

期刊介绍： Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.