Inhibitory leukocyte immunoglobulin-like receptors, subfamily B (LILRBs) in human diseases: structure, roles, mechanisms, and clinical applications.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-07-25 eCollection Date: 2025-01-01 DOI:10.7150/thno.116951
Yuxiu Zhang, Yuanyuan Xu, Qihui Wu, Xiaodan Fu, Yimin Li, Anqi Li
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引用次数: 0

Abstract

Leukocyte immunoglobulin-like receptors, subfamily B (LILRBs), are a class of critical immunosuppressive receptors that contribute to immune homeostasis by transmitting suppressive signals upon binding to ligands such as major histocompatibility complex class I molecules. They play key roles in modulating both innate and adaptive immune responses. This review summarizes the structural features, ligand interactions, signaling pathways, and expression regulation of LILRBs, and discusses their roles in immune cell function and disease progression, particularly in the tumor microenvironment. We also review current progress in the development of LILRB-targeted therapies for hematological malignancies and solid tumors and outline the challenges and future directions in translating these findings into clinical applications. By integrating recent advances, this review provides a framework for understanding the potential of LILRBs as therapeutic targets in cancer and immune-related disorders.

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抑制性白细胞免疫球蛋白样受体B亚家族(LILRBs)在人类疾病中的结构、作用、机制和临床应用
白细胞免疫球蛋白样受体,B亚家族(LILRBs)是一类重要的免疫抑制受体,通过与配体(如主要组织相容性复合体I类分子)结合传递抑制信号来促进免疫稳态。它们在调节先天和适应性免疫反应中发挥关键作用。本文综述了LILRBs的结构特征、配体相互作用、信号通路和表达调控,并讨论了它们在免疫细胞功能和疾病进展中的作用,特别是在肿瘤微环境中的作用。我们还回顾了目前针对血液系统恶性肿瘤和实体肿瘤的lilrb靶向治疗的进展,并概述了将这些发现转化为临床应用的挑战和未来方向。通过整合最近的进展,本综述为理解LILRBs作为癌症和免疫相关疾病的治疗靶点的潜力提供了一个框架。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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