Association Between Dead Space to Tidal Volume Ratio and Duration of Respiratory Support After Extubation in Children With Congenital Heart Disease.

Abstract

Background: Children with cardiac disease liberated from mechanical ventilation often receive noninvasive respiratory support (NRS) postextubation via high-flow nasal cannula, CPAP, or noninvasive ventilation. Predicting the type and duration of postextubation NRS can be challenging due to a lack of objective tools to guide decision-making. The dead space to tidal volume ratio (V_D/V_T) is a potential tool to guide this decision. We hypothesized that an elevated V_D/V_T would be associated with longer duration and higher level of NRS following extubation in children with cardiac disease. Methods: We conducted a retrospective cohort study of mechanically ventilated patients admitted to our pediatric cardiac intensive care unit between March 2019 and July 2021 with at least one V_D/V_T recorded before extubation. Subjects were dichotomized a priori into two groups V_D/V_T < 0.30 and V_D/V_T ≥ 0.30. We recorded the type of NRS at 24 hours, 48 hours, 72 hours, 7 days, and 14 days after extubation. Results: We included 226 subjects. Median (IQR) weight was 4.1 (3.3-6.6) kg, 47% were female, 47% had cyanotic heart disease, and 90% were mechanically ventilated for respiratory failure or cardiac surgery. Subjects with V_D/V_T ≥ 0.30 experienced longer postextubation NRS (4 [1.9-9.1] vs 3 [1.2-5.3] days, P = .001) and were more likely to receive high-flow nasal cannula (67% vs 45%, P = .02) 24 hours following extubation. NRS modality immediately postextubation and reintubtion rates were similar between groups. Subjects with V_D/V_T ≥ 0.30 were younger (1.2 [0.1-3.6] vs 4.8 [1.2-30] months, P < .001) and more likely to have cyanotic congenital heart disease (59% vs 26%, P < .001). After adjusting for demographic and clinical characteristics, V_D/V_T was not associated with NRS use. Conclusion: V_D/V_T was not associated with the length of NRS after extubation or re-intubation after controlling for demographic and clinical differences.