Prevalence and Risk Factors for Bladder and Bowel Dysfunction in Children With Type 1 Diabetes.

IF 5.6 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Pediatric Diabetes Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.1155/pedi/5294835

Kristen Favel, Maryellen S Kelly, Shing Tat Theodore Lam, Jeffrey N Bone, Kathryn E Morgan, Heidi A Stephany, Sruthi Thomas, Kourosh Afshar, Constadina Panagiotopoulos

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引用次数: 0

Abstract

Background: Urologic complications, including urinary incontinence and urinary tract infections are commonly observed in the adult population with type 1 diabetes (T1D); however, there remains a paucity of data on the prevalence, associated risk factors and impact of bowel and bladder dysfunction (BBD) in the pediatric T1D population. Aim: This study aims to examine the prevalence of BBD in children with T1D compared to healthy pediatric controls and to explore clinical factors associated with childhood BBD. Methods: This cross-sectional, noninterventional, multicenter survey study involved children with TID and healthy controls aged 5-16 years across North America. Participants and their caregivers completed the Vancouver Symptom Score (VSS) to assess bowel and bladder symptoms. BBD was defined as a total VSS score of 11 or greater. Logistic regression was used to identify potential factors associated with BBD and bother with symptoms. Results: In a group of 242 participants with T1D and 86 controls, 46% were male, and the median age was 11.0 years. The prevalence of BBD was found to be higher in participants with T1D at 21.5%, compared to 10.5% in controls. While irritative symptoms were most commonly reported in the T1D group with BBD, urinary incontinence caused the most bother. In the T1D group, poorer glycemic control was linked to a greater likelihood of BBD, while male sex and more severe symptomatology (such as urinary incontinence) were associated with greater bother related to these symptoms. Conclusion: There is a high prevalence of BBD in children with T1D compared to healthy controls. These data highlight the need for early identification and intervention for BBD in T1D. Proactive measures, such as routine screening and comprehensive T1D management with strict attention to glycemic control, are crucial to address the significant burden of BBD and improve overall health outcomes for children with T1D and their families.

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1型糖尿病儿童膀胱和肠功能障碍的患病率及危险因素

背景：泌尿系统并发症，包括尿失禁和尿路感染，在1型糖尿病（T1D）的成年人群中很常见；然而，关于儿童T1D人群中肠道和膀胱功能障碍（BBD）的患病率、相关危险因素和影响的数据仍然缺乏。目的：本研究旨在研究与健康儿童对照相比，T1D儿童BBD的患病率，并探讨与儿童BBD相关的临床因素。方法：这项横断面、非介入性、多中心调查研究涉及北美地区5-16岁的TID患儿和健康对照。参与者及其护理人员完成温哥华症状评分（VSS）来评估肠道和膀胱症状。BBD被定义为VSS总分为11分或更高。Logistic回归用于确定与BBD和症状相关的潜在因素。结果：在242例T1D患者和86例对照组中，46%为男性，中位年龄为11.0岁。与对照组的10.5%相比，T1D患者的BBD患病率更高，为21.5%。虽然T1D组伴有BBD的患者最常出现刺激性症状，但尿失禁引起的困扰最大。在T1D组中，较差的血糖控制与更大的BBD可能性有关，而男性和更严重的症状（如尿失禁）与这些症状相关的更大麻烦有关。结论：与健康对照相比，T1D患儿BBD患病率较高。这些数据强调了早期识别和干预T1D患者BBD的必要性。积极的措施，如常规筛查和全面的T1D管理，严格关注血糖控制，对于解决BBD的重大负担和改善T1D儿童及其家庭的整体健康结果至关重要。

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来源期刊

Pediatric Diabetes 医学-内分泌学与代谢

CiteScore

6.60

自引率

14.70%

发文量

141

审稿时长

4-8 weeks

期刊介绍： Pediatric Diabetes is a bi-monthly journal devoted to disseminating new knowledge relating to the epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes in childhood and adolescence. The aim of the journal is to become the leading vehicle for international dissemination of research and practice relating to diabetes in youth. Papers are considered for publication based on the rigor of scientific approach, novelty, and importance for understanding mechanisms involved in the epidemiology and etiology of this disease, especially its molecular, biochemical and physiological aspects. Work relating to the clinical presentation, course, management and outcome of diabetes, including its physical and emotional sequelae, is considered. In vitro studies using animal or human tissues, whole animal and clinical studies in humans are also considered. The journal reviews full-length papers, preliminary communications with important new information, clinical reports, and reviews of major topics. Invited editorials, commentaries, and perspectives are a regular feature. The editors, based in the USA, Europe, and Australasia, maintain regular communications to assure rapid turnaround time of submitted manuscripts.