Developing an EQ-5D-5L Value Set for Singapore.

IF 4.6 3区医学 Q1 ECONOMICS

PharmacoEconomics Pub Date : 2025-08-29 DOI:10.1007/s40273-025-01519-7

Nan Luo, Annushiah Vasan Thakumar, Ling Jie Cheng, Zhihao Yang, Kim Rand, Yin Bun Cheung, Julian Thumboo

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引用次数: 0

Abstract

Objectives: The EQ-5D-5L is a multi-attribute utility instrument recommended by many health technology assessment agencies. This study aimed to develop an EQ-5D-5L value set for Singapore.

Methods: A 'lite' version of the EuroQol Research Foundation's EQ-5D-5L valuation protocol, which was designed to value a total of 91 health states using a composite time trade-off (cTTO) method, was followed. Five hundred members of the general public in Singapore were quota-sampled and invited to a personal interview face-to-face or via Zoom. All participants completed 20 cTTO tasks administered using the EuroQol Valuation Technology (EQ-VT) program. Cross-validation analysis was performed to identify the best-performing model for estimating the values of all the 3,125 EQ-5D-5L health states.

Results: A 20-parameter main-effects model with two two-way interaction terms outperformed other models in the cross-validation analysis. The value set estimated using this model ranges from - 0.851 (for state 55555) to 1.000 (for state 11111), with pain/discomfort and anxiety/depression dimensions associated with the greatest disutility.

Conclusions: We developed an EQ-5D-5L value set based on the health preferences of Singaporeans. We recommend EQ-5D-5L users in Singapore to use this value set and encourage a more systematic and dedicated methodological effort to understand interaction effects and potential non-linearities in the valuation of multi-attribute health descriptive systems.

查看原文本刊更多论文

为新加坡开发EQ-5D-5L值集。

目的：EQ-5D-5L是多家卫生技术评估机构推荐的多属性实用仪器。本研究旨在为新加坡开发EQ-5D-5L值集。方法：遵循EuroQol研究基金会的EQ-5D-5L评估方案的“精简版”，该方案旨在使用复合时间权衡（cTTO）方法对总共91种健康状态进行评估。500名新加坡普通民众被按配额抽样，并被邀请面对面或通过Zoom进行个人采访。所有参与者都完成了使用EuroQol评估技术（EQ-VT）程序管理的20个cTTO任务。进行交叉验证分析，以确定评估所有3125个EQ-5D-5L健康状态值的最佳模型。结果：具有两个双向交互项的20参数主效应模型在交叉验证分析中优于其他模型。使用该模型估计的值集范围从- 0.851（状态55555）到1.000（状态11111），疼痛/不适和焦虑/抑郁维度与最大的负效用相关。结论：我们根据新加坡人的健康偏好制定了EQ-5D-5L值集。我们建议新加坡的EQ-5D-5L用户使用这个值集，并鼓励更系统和专门的方法努力来理解多属性健康描述性系统评估中的相互作用效应和潜在的非线性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

PharmacoEconomics 医学-药学

CiteScore

8.10

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： PharmacoEconomics is the benchmark journal for peer-reviewed, authoritative and practical articles on the application of pharmacoeconomics and quality-of-life assessment to optimum drug therapy and health outcomes. An invaluable source of applied pharmacoeconomic original research and educational material for the healthcare decision maker. PharmacoEconomics is dedicated to the clear communication of complex pharmacoeconomic issues related to patient care and drug utilization. PharmacoEconomics offers a range of additional features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by a Key Points summary, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand the scientific content and overall implications of the article.