The Dark Side of NK Cells in Cancer Immunotherapy.

IF 33.3 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2025-09-04 DOI:10.1158/2159-8290.cd-25-1042

Felipe Galvez-Cancino,Maria Armero,David R Withers,Paula Molero-Glez,Ana Melero,Belen Palencia,Ignacio Melero

引用次数: 0

Abstract

NK cells are a subset of innate lymphoid cells originally identified in mice and humans based on their ability to mediate cytotoxicity against transformed cells. However, two recent back-to-back studies in this issue of Cancer Discovery reveal that NK cell infiltration is not always beneficial; rather, it can impair the efficacy of immune checkpoint blockade through immune-regulatory mechanisms. See related article by Pozniak et al., p. 1819 See related article by Song et al., p. 1835.

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NK细胞在癌症免疫治疗中的阴暗面。

NK细胞是先天淋巴样细胞的一个子集，最初在小鼠和人类中发现，基于它们介导细胞毒性的能力。然而，最近在本期《癌症发现》杂志上发表的两项连续研究表明，NK细胞浸润并不总是有益的；相反，它可以通过免疫调节机制削弱免疫检查点封锁的功效。参见Pozniak et al., p. 1819的相关文章参见Song et al., p. 1835的相关文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.