Sex Differences in Opioid Misuse among Adults with Chronic Lower Back Pain: The Roles of Negative Affect and Related Transdiagnostic Factors.

IF 0.6 4区医学 Q4 SUBSTANCE ABUSE

Journal of Substance Use Pub Date : 2025-02-09 DOI:10.1080/14659891.2025.2461288

Julia D Buckner, Caroline R Scherzer, Luke A Vargo, Paige E Morris, Andrew H Rogers, Michael J Zvolensky

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引用次数: 0

Abstract

Background: The opioid epidemic is a significant public health concern, particularly among adults with chronic pain. Although sex differences in opioid-related behaviors have been observed, little work has examined the role of negative affect and related variables in greater opioid misuse severity risk among men.

Methods: We tested whether, among 206 (72.3% female) adults (aged 18-64, M = 45.5) with chronic lower back pain (CLBP), the relation of sex with opioid misuse severity would be moderated by a range of negative affect-related variables (anxiety, depression, pain anxiety, pain catastrophizing, difficulty with emotion regulation, anxiety sensitivity, and distress intolerance).

Results: Although these negative affect-related variables were related to more severe opioid misuse for both men and women, the relation of sex to misuse varied as a function of the following variables: anxiety, pain anxiety, pain catastrophizing, and difficulty with emotion regulation, such that at higher levels of these variables, men reported more severe opioid misuse than women. This same pattern was not evident for depression, anxiety sensitivity, or distress intolerance.

Conclusions: Results highlight the important roles specific types of negative affect-related variables may play in observed sex differences in opioid misuse severity among individuals with CLBP.

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成人慢性下背痛阿片类药物滥用的性别差异：负面情绪和相关的跨诊断因素的作用

背景：阿片类药物流行是一个重大的公共卫生问题，特别是在患有慢性疼痛的成年人中。虽然已经观察到阿片类药物相关行为的性别差异，但很少有工作研究负面影响和相关变量在男性阿片类药物滥用严重程度风险中的作用。方法：我们测试了206例（72.3%为女性）患有慢性下背痛（CLBP）的成年人（18-64岁，M = 45.5），性别与阿片类药物滥用严重程度的关系是否会被一系列负面情绪相关变量（焦虑、抑郁、疼痛焦虑、疼痛灾难化、情绪调节困难、焦虑敏感性和痛苦不耐受）所调节。结果：尽管这些负面影响相关变量与男性和女性更严重的阿片类药物滥用有关，但性别与滥用的关系作为以下变量的函数而变化：焦虑、疼痛焦虑、疼痛灾难化和情绪调节困难，因此在这些变量的较高水平上，男性报告的阿片类药物滥用比女性更严重。同样的模式在抑郁症、焦虑敏感性或痛苦不耐受中并不明显。结论：研究结果强调了特定类型的负面情绪相关变量可能在观察到的CLBP个体阿片类药物滥用严重程度的性别差异中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Substance Use SUBSTANCE ABUSE-

CiteScore

1.60

自引率

0.00%

发文量

129

期刊介绍： Journal of Substance Use is a bimonthly international journal, publishing peer-reviewed, up-to-the-minute articles on a wide spectrum of issues relating to the use of legal and illegal substances. The Journal aims to educate, inform, update and act as a forum for standard setting for health and social care professionals working with individuals and families with substance use problems. It also informs and supports those undertaking research in substance use, developing substance use services, and participating in, leading and developing education and training programmes.