Tatsat Banerjee, Yu Deng, Dhiman Sankar Pal, Huiwang Zhan, Pablo A Iglesias, Peter N Devreotes
{"title":"Signaling and actin waves at a glance.","authors":"Tatsat Banerjee, Yu Deng, Dhiman Sankar Pal, Huiwang Zhan, Pablo A Iglesias, Peter N Devreotes","doi":"10.1242/jcs.263634","DOIUrl":null,"url":null,"abstract":"<p><p>Waves of signaling and cytoskeletal components, which can be easily seen propagating on the ventral surface of a cell, are a systemic feature of biochemical networks that define the spatiotemporal dynamics of diverse cell physiological processes. In this Cell Science at a Glance article and the accompanying poster, we summarize the origin, mathematical basis, and function of signaling and actin waves from systems biology and biophysics perspectives, focusing on cell migration and polarity. We describe how waves control membrane protrusion morphologies, how different proteins and lipids are organized within the waves by distinct mechanisms, and how excitable network-based mathematical models can explain wave patterns and predict cell behavior. We further delineate how specific components interact biochemically to generate these dynamic patterns. Finally, we provide a set of generalizable underlying biophysical principles to describe the exquisite subcellular organization of signaling and cytoskeletal events, membrane symmetry breaking, protein compartmentalization and wave propagation.</p>","PeriodicalId":15227,"journal":{"name":"Journal of cell science","volume":"138 16","pages":""},"PeriodicalIF":3.6000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380181/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cell science","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1242/jcs.263634","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Waves of signaling and cytoskeletal components, which can be easily seen propagating on the ventral surface of a cell, are a systemic feature of biochemical networks that define the spatiotemporal dynamics of diverse cell physiological processes. In this Cell Science at a Glance article and the accompanying poster, we summarize the origin, mathematical basis, and function of signaling and actin waves from systems biology and biophysics perspectives, focusing on cell migration and polarity. We describe how waves control membrane protrusion morphologies, how different proteins and lipids are organized within the waves by distinct mechanisms, and how excitable network-based mathematical models can explain wave patterns and predict cell behavior. We further delineate how specific components interact biochemically to generate these dynamic patterns. Finally, we provide a set of generalizable underlying biophysical principles to describe the exquisite subcellular organization of signaling and cytoskeletal events, membrane symmetry breaking, protein compartmentalization and wave propagation.
信号波和细胞骨架成分可以很容易地在细胞的腹表面传播,是生物化学网络的一个系统特征,它定义了不同细胞生理过程的时空动态。在这篇Cell Science at a Glance文章和随附的海报中,我们从系统生物学和生物物理学的角度总结了信号和肌动蛋白波的起源、数学基础和功能,重点是细胞迁移和极性。我们描述了波是如何控制膜突起形态的,不同的蛋白质和脂质是如何通过不同的机制在波中组织的,以及基于兴奋网络的数学模型是如何解释波的模式和预测细胞行为的。我们进一步描述了特定成分如何通过生物化学相互作用来产生这些动态模式。最后,我们提供了一套可概括的潜在生物物理原理来描述信号和细胞骨架事件,膜对称破坏,蛋白质区隔化和波传播的精致亚细胞组织。