Basement membranes at a glance.

IF 3.6 3区 生物学 Q3 CELL BIOLOGY
Journal of cell science Pub Date : 2025-09-01 Epub Date: 2025-09-03 DOI:10.1242/jcs.263947
Rachel Lennon, David R Sherwood
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引用次数: 0

Abstract

Basement membranes (BMs) underlie or surround most tissues. They are formed of secreted proteins that associate with cell surfaces and are the most ancient animal extracellular matrix. Laminin and collagen IV are core components that polymerize into self-associating networks, providing BMs with an organizing scaffold and tensile strength. In humans, BMs also contain over 150 other secreted proteins, such as structural matrix components, enzymes and growth factors, as well as over 50 cell-membrane adhesion and signalling receptors. From this toolbox, BMs are tailored for tissue-specific functions, including filtration, shaping organs, connecting tissues and harbouring signals that guide cell migration and differentiation. Highlighting their importance to human health, defects in genes encoding BM proteins are associated with over 100 disease phenotypes. Advancing our understanding of BM regulation, function and dysregulation will reveal new approaches to prevent many human disorders and preserve tissue health. Here, we review our current understanding of BM composition, formation and function, and outline how BMs change with ageing and disease.

基膜一目了然。
基底膜(BMs)在大多数组织下面或周围。它们是由与细胞表面相关的分泌蛋白形成的,是最古老的动物细胞外基质。层粘连蛋白和胶原IV是聚合成自结合网络的核心成分,为脑转移瘤提供组织支架和抗拉强度。在人体中,脑转移瘤还含有150多种其他分泌蛋白,如结构基质成分、酶和生长因子,以及50多种细胞膜粘附和信号受体。从这个工具箱中,脑转移瘤被定制为组织特异性功能,包括过滤,塑造器官,连接组织和庇护引导细胞迁移和分化的信号。编码BM蛋白的基因缺陷与100多种疾病表型相关,这突出了它们对人类健康的重要性。推进我们对脑基质调节、功能和失调的理解将揭示预防许多人类疾病和保持组织健康的新方法。在这里,我们回顾了目前对脑基组成、形成和功能的理解,并概述了脑基如何随着年龄和疾病而变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of cell science
Journal of cell science 生物-细胞生物学
CiteScore
7.30
自引率
2.50%
发文量
393
审稿时长
1.4 months
期刊介绍: Journal of Cell Science publishes cutting-edge science, encompassing all aspects of cell biology.
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