Role of the extracellular matrix in amylin aggregation: Opportunities for improved therapy in type 2 diabetes mellitus.

IF 1.9 4区 生物学 Q2 BIOLOGY
Journal of Biosciences Pub Date : 2025-01-01
Sagarika Prabhakar, Priyadarshini Veerabhadraswamy, Nikhil R Gandasi
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引用次数: 0

Abstract

In most individuals with type 2 diabetes mellitus (T2DM), aggregation of amylin or islet amyloid polypeptide (IAPP) leads to β-cell apoptosis, impairs glucose-stimulated insulin secretion, and causes islet disorganisation (Cooper et al. 1987; Westermark and Westermark 2000). Amylin is sorted within the immature secretory granules (ISGs) of pancreatic β-cells and co-secreted with insulin upon nutrient stimulation to regulate metabolism. Under normal conditions, it remains soluble in ISGs due to its low concentration and is stabilised by insulin and zinc, in an acidic environment (Westermark et al. 1987; Janson et al. 1996; Abedini and Raleigh 2006). However, under stress or with overproduction of amylin, it aggregates into insoluble amyloid fibrils both intracellularly and extracellularly after secretion (Gurlo et al. 2010).

细胞外基质在胰淀素聚集中的作用:改善2型糖尿病治疗的机会
在大多数2型糖尿病(T2DM)患者中,胰淀素或胰岛淀粉样多肽(IAPP)的聚集导致β细胞凋亡,损害葡萄糖刺激的胰岛素分泌,并导致胰岛组织紊乱(Cooper et al. 1987; Westermark and Westermark 2000)。胰淀素分选于胰腺β细胞的未成熟分泌颗粒(ISGs)内,在营养刺激下与胰岛素共同分泌,调节代谢。在正常条件下,由于其浓度低,它在酸性环境中仍可溶解于isg中,并被胰岛素和锌稳定(Westermark et al. 1987; Janson et al. 1996; Abedini and Raleigh 2006)。然而,在应激或胰淀素过量产生的情况下,胰淀素分泌后在细胞内和细胞外聚集成不溶性淀粉样蛋白原纤维(Gurlo et al. 2010)。
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来源期刊
Journal of Biosciences
Journal of Biosciences 生物-生物学
CiteScore
5.80
自引率
0.00%
发文量
83
审稿时长
3 months
期刊介绍: The Journal of Biosciences is a quarterly journal published by the Indian Academy of Sciences, Bangalore. It covers all areas of Biology and is the premier journal in the country within its scope. It is indexed in Current Contents and other standard Biological and Medical databases. The Journal of Biosciences began in 1934 as the Proceedings of the Indian Academy of Sciences (Section B). This continued until 1978 when it was split into three parts : Proceedings-Animal Sciences, Proceedings-Plant Sciences and Proceedings-Experimental Biology. Proceedings-Experimental Biology was renamed Journal of Biosciences in 1979; and in 1991, Proceedings-Animal Sciences and Proceedings-Plant Sciences merged with it.
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