Quantitative CT analysis for predicting the PD-L1 expression in lung adenocarcinoma.

IF 2.1 4区医学

Japanese Journal of Radiology Pub Date : 2025-08-26 DOI:10.1007/s11604-025-01857-8

Masaya Tanabe, Yoshie Kunihiro, Masahiro Tanabe, Fumi Kameda, Masatoshi Nakashima, Taiga Kobayashi, Toshiki Tanaka, Yoshinobu Hoshii, Katsuyoshi Ito

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引用次数: 0

Abstract

Purpose: The objective of this study was to explore the relationship between a quantitative CT analysis and the expression of programmed death-ligand 1 (PD-L1) in lung adenocarcinoma.

Materials and methods: This study included 116 patients diagnosed with lung adenocarcinoma who were assessed for the expression of PD-L1. Tumors were classified as pure ground-glass nodules (GGNs), part-solid nodules, and solid nodules. The quantitative CT analysis included the tumor diameter and volume, solid component diameter and volume, and rate of the solid components. The CT criteria, and PD-L1 expression rates were compared based on the tumor proportion score (TPS). Optimal cutoff values were obtained utilizing the maximized Youden index method based on the receiver operating characteristic (ROC) analysis. Univariate and multiple linear regression analyses were also performed to examine the influencing factors of 50% and 1% PD-L1 expression.

Results: Solid nodules were significantly more frequent in the TPS ≥ 50% group (TPS ≥ 50% = 81.8% vs. TPS < 1% = 10.0%). The rate of solid component diameter and rate of solid component volume were significantly smaller in TPS < 1% than in TPS < 50% and 1-49% (p < 0.001, respectively). Multiple linear regression analysis identified the rate of solid component volume as a significant factor influencing 50% and 1% PD-L1 expression (p < 0.001 and p = 0.048, respectively).

Conclusion: High PD-L1 expression rates may be associated with higher rates of solid components in lung adenocarcinoma.

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定量CT分析预测肺腺癌组织中PD-L1表达。

目的：本研究的目的是探讨定量CT分析与肺腺癌中程序性死亡配体1 （PD-L1）表达的关系。材料和方法：本研究纳入116例诊断为肺腺癌的患者，评估PD-L1的表达。肿瘤分为纯磨玻璃结节（ggn）、部分实性结节和实性结节。CT定量分析包括肿瘤直径和体积、实性成分直径和体积、实性成分发生率。根据肿瘤比例评分（TPS）比较CT标准和PD-L1表达率。采用基于受试者工作特征（ROC）分析的最大化约登指数法获得最佳截止值。单因素和多元线性回归分析分别检测50%和1% PD-L1表达的影响因素。结果：TPS≥50%组实性结节发生率明显高于TPS组（TPS≥50% = 81.8%）。结论：高PD-L1表达率可能与肺腺癌中较高的实性成分发生率相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Radiology Medicine-Radiology, Nuclear Medicine and Imaging

自引率

4.80%

发文量

133

期刊介绍： Japanese Journal of Radiology is a peer-reviewed journal, officially published by the Japan Radiological Society. The main purpose of the journal is to provide a forum for the publication of papers documenting recent advances and new developments in the field of radiology in medicine and biology. The scope of Japanese Journal of Radiology encompasses but is not restricted to diagnostic radiology, interventional radiology, radiation oncology, nuclear medicine, radiation physics, and radiation biology. Additionally, the journal covers technical and industrial innovations. The journal welcomes original articles, technical notes, review articles, pictorial essays and letters to the editor. The journal also provides announcements from the boards and the committees of the society. Membership in the Japan Radiological Society is not a prerequisite for submission. Contributions are welcomed from all parts of the world.