Exploring cerebral small vessel disease, choroid plexus, demographics and vascular risk factors that affect glymphatic function.

IF 2.1 4区医学

Japanese Journal of Radiology Pub Date : 2025-08-27 DOI:10.1007/s11604-025-01843-0

Yiwen Chen, Linfeng Yang, Meng Li, Pengcheng Liang, Zhenyu Cheng, Na Wang, Xinyue Zhang, Yu Wang, Changhu Liang, Jing Li, Lingfei Guo

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引用次数: 0

Abstract

Background: Cerebral small vessel disease (CSVD) is a major contributor to cognitive decline and dementia. The glymphatic system, a recently discovered brain waste clearance system, plays a critical role in maintaining brain health. This study investigates glymphatic dysfunction in CSVD using diffusion tensor imaging along perivascular spaces (DTI-ALPS) and enlarged perivascular spaces (EPVS), to identify key risk factors and modifiable influences.

Methods: 373 participants were recruited and underwent magnetic resonance imaging. Multivariable regression and restricted cubic splines (RCS) were performed to investigate the associations between demographics, vascular risk factors, choroid plexus volume (CPV), imaging markers of CSVD, and time of day (TOD) with the glymphatic system estimated by DTI-ALPS and PVS.

Results: L-ALPS correlated with age (β = - 0.233, p < 0.001), CPV (β = - 0.100, p = 0.047), and sex (β = 0.103, p = 0.027). R-ALPS correlated with age (β = - 0.108, p = 0.040), Fazekas score (β = - 0.151, p = 0.006), male sex (β = 0.209, p < 0.001), and cerebral microbleeds (β = - 0.146, p = 0.004). The risk factors for severe BG-PVS were age (OR: 1.090, P < 0.001) and Fazekas score (OR: 2.243, P < 0.001). L-ALPS correlated with TOD (β = - 0.091, p = 0.039), particularly in females (β = - 0.147, p = 0.016).

Conclusion: Age, sex (male), white matter hyperintensity, CPV enlargement, and cerebral microbleeds are risk factors for glymphatic dysfunction. Circadian rhythms may modulate glymphatic activity.

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探讨脑血管疾病、脉络膜丛、人口统计学和影响淋巴功能的血管危险因素。

背景：脑血管病（CSVD）是认知能力下降和痴呆的主要诱因。淋巴系统是最近发现的大脑废物清除系统，在维持大脑健康方面起着至关重要的作用。本研究利用沿血管周围间隙扩散张量成像（DTI-ALPS）和血管周围间隙扩大（EPVS）研究CSVD的淋巴功能障碍，以确定关键危险因素和可改变的影响。方法：招募373名参与者并进行磁共振成像。采用多变量回归和限制性三次样条（RCS）研究人口统计学、血管危险因素、脉络膜丛体积（CPV）、CSVD成像标志物和白天时间（TOD）与DTI-ALPS和PVS估计的淋巴系统之间的关系。结果：L-ALPS与年龄相关（β = - 0.233, p）。结论：年龄、性别（男性）、白质高、CPV增大、脑微出血是淋巴功能障碍的危险因素。昼夜节律可能调节淋巴细胞的活动。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Journal of Radiology Medicine-Radiology, Nuclear Medicine and Imaging

自引率

4.80%

发文量

133

期刊介绍： Japanese Journal of Radiology is a peer-reviewed journal, officially published by the Japan Radiological Society. The main purpose of the journal is to provide a forum for the publication of papers documenting recent advances and new developments in the field of radiology in medicine and biology. The scope of Japanese Journal of Radiology encompasses but is not restricted to diagnostic radiology, interventional radiology, radiation oncology, nuclear medicine, radiation physics, and radiation biology. Additionally, the journal covers technical and industrial innovations. The journal welcomes original articles, technical notes, review articles, pictorial essays and letters to the editor. The journal also provides announcements from the boards and the committees of the society. Membership in the Japan Radiological Society is not a prerequisite for submission. Contributions are welcomed from all parts of the world.