Epidermal growth factor receptor inhibitor-related skin toxicities: a review of management and possible preventive and therapeutic approaches for Asian patients by the Japanese Pharmacist-led Oncodermatology Study Team.

Abstract

Epidermal growth factor receptor antibodies and tyrosine kinase inhibitors cause various skin toxicities. Acneiform rash, paronychia, and pruritus are the major side effects, and their incidence is high, especially in Asian patients. These skin disorders greatly reduce the patients' quality of life and can affect treatment intensity. As the incidence and severity of these skin toxicities correlate with treatment effects, adequate management during the treatment period is essential. Guidelines and treatment recommendations exist for epidermal growth factor receptor inhibitor-related skin toxicities. However, there have been no previous reviews of studies on Asian patients. In this review, we discuss the possible preventive and therapeutic recommendations for Asian patients. We derived recommendations based on evidence from Asian patients. This review will contribute to the management of these toxicities in Asian populations.