Dental Management for People With Congenital Haemophilia: A Systematic Review of the Existing Dental Recommendations

IF 3 2区医学 Q2 HEMATOLOGY

Haemophilia Pub Date : 2025-08-21 DOI:10.1111/hae.70104

Mathangi Kumar, Sulochana Badagabettu, Keerthilatha M. Pai, Judith Angelitta Noronha, Baby S. Nayak, Penny McCarthy

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Abstract

Introduction

Haemophilia is the most common inherited bleeding disorder. Dental management for people with haemophilia (PwH) (both A and B) is challenging, as dental procedures may initiate bleeding episodes that may be difficult to control.

Objectives

This systematic review aimed to evaluate and summarize the existing dental guidelines that are proposed from various agencies/professional bodies, and so forth, for dental treatment procedures in PwH.

Methods

A systematic electronic search on databases like Scopus, Medline, EMBASE, CINAHL, ProQuest and Web of Science was performed. The parameters evaluated were (a) clotting factor replacement therapy employed, (b) haemostatic agents, both local and systemic therapy and (c) dental procedural and pharmacological considerations that are recommended before, during, and after dental treatment procedures for people with mild, moderate and severe haemophilia. The dental treatment procedures included all minor and major procedures, including surgical extraction of wisdom teeth.

Results

A total of 11 guidelines were included for data extraction. The results indicated that all guidelines emphasized the importance of close collaboration among haematologists and dental professionals to ensure safe and effective dental treatment as a key component of comprehensive dental care. The various dental treatments (restorative, periodontal, orthodontic and prosthodontic treatments) and preventive aspects of oral health are detailed. Also, the amount of clotting factor replacement therapy for dental procedures, and pharmacological considerations recommended from the various professional organizations are discussed.

Conclusion

Well-designed large-scale research initiatives in dental management for PwH are necessary to understand the applicability and outcomes of such guidelines in clinical practice.

Trial Registration: REF/2024/01/077096

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先天性血友病患者的牙科治疗：现有牙科建议的系统回顾。

血友病是最常见的遗传性出血性疾病。血友病患者（A型和B型）的牙科治疗具有挑战性，因为牙科治疗可能引发难以控制的出血发作。目的：本系统综述旨在评估和总结各机构/专业团体等对PwH牙科治疗程序提出的现有牙科指南。方法：系统电子检索Scopus、Medline、EMBASE、CINAHL、ProQuest、Web of Science等数据库。评估的参数包括：(a)使用的凝血因子替代疗法，(b)局部和全身治疗的止血剂，以及(c)轻度、中度和重度血友病患者在牙科治疗之前、期间和之后推荐的牙科程序和药理学考虑。牙科治疗程序包括所有大小程序，包括智齿的手术拔除。结果：共纳入11条指南进行数据提取。结果表明，所有指南都强调血液病学家和牙科专业人员之间密切合作的重要性，以确保安全有效的牙科治疗作为全面牙科护理的关键组成部分。各种牙科治疗（修复，牙周，正畸和修复治疗）和口腔健康的预防方面的细节。此外，凝血因子替代治疗的牙科程序的量和药理学的考虑建议从各种专业组织进行了讨论。结论：为了解该指南在临床实践中的适用性和效果，有必要对PwH牙科管理进行精心设计的大规模研究。试验注册：REF/2024/01/077096。

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来源期刊

Haemophilia 医学-血液学

CiteScore

6.50

自引率

28.20%

发文量

226

审稿时长

3-6 weeks

期刊介绍： Haemophilia is an international journal dedicated to the exchange of information regarding the comprehensive care of haemophilia. The Journal contains review articles, original scientific papers and case reports related to haemophilia care, with frequent supplements. Subjects covered include: clotting factor deficiencies, both inherited and acquired: haemophilia A, B, von Willebrand''s disease, deficiencies of factor V, VII, X and XI replacement therapy for clotting factor deficiencies component therapy in the developing world transfusion transmitted disease haemophilia care and paediatrics, orthopaedics, gynaecology and obstetrics nursing laboratory diagnosis carrier detection psycho-social concerns economic issues audit inherited platelet disorders.