Post-surgery recurrence predictors for stage I-II endometrial carcinoma: a retrospective observational study.

IF 2.6 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2025-09-01 Epub Date: 2025-08-22 DOI:10.1080/14796694.2025.2546281

Yushan Li, Hongli Wang, Shuyun Zhao

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引用次数: 0

Abstract

Purpose: A retrospective observational study was conducted to investigate the predictors for recurrence of stage I-II endometrial cancer after surgical treatment.

Methods: 130 stage I-II endometrioid carcinoma patients receiving laparoscopic surgery in Jincheng People's Hospital from January 2019 to January 2022 were retrospectively selected and diagnosed via HE assay. Their clinic and histology characteristics were collected. Kaplan-Meier survival analysis was to analyze the effect of chemotherapy and radiotherapy on the survival rate of the recurrent patients. Multivariate analysis was to explore the factors affecting postoperative recurrence.

Results: Diagnosis was confirmed by diagnostic curettage in 129 cases. In 130 patients, the invading of superficial myometrium and deep myometrium was more obvious. After chemotherapy and radiotherapy treatment, the 5-year survival rate was 78.46%, and it was different among two therapies; (p = 0.006). Pathological type, disease stage, histological grade and myometrial invasion were the risk factors for recurrence. No significant difference in endometrioid adenocarcinoma proportion between 50 years old and ≤50 years old; (p > 0.05).

Conclusion: The Stage I-II endometrial cancer recurrence after laparoscopic surgery can be judged by pathological type, disease stage, histological grade and myometrial invasion, providing theoretical basis for disease treatment to reduce the recurrence and improve the prognosis.

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I-II期子宫内膜癌术后复发预测因素：一项回顾性观察性研究。

目的：回顾性观察研究I-II期子宫内膜癌手术治疗后复发的预测因素。方法：回顾性选择2019年1月至2022年1月在金城市人民医院行腹腔镜手术的I-II期子宫内膜样癌患者130例，采用HE法诊断。收集患者的临床及组织学特征。Kaplan-Meier生存分析是分析化疗和放疗对复发患者生存率的影响。通过多因素分析探讨影响术后复发的因素。结果：129例经诊断刮痧确诊。130例患者中，浅肌层和深肌层的侵犯更为明显。化疗和放疗后5年生存率为78.46%，两种治疗方法差异较大；（p = 0.006）。病理类型、疾病分期、组织学分级及肌层浸润是复发的危险因素。50岁与≤50岁子宫内膜样腺癌比例无显著差异；（p < 0.05）。结论：腹腔镜手术后I-II期子宫内膜癌复发可通过病理分型、疾病分期、组织学分级及子宫肌层侵犯情况判断，为疾病治疗提供理论依据，减少复发，改善预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.