Fecal leukocyte esterase levels predict endoscopic severity as an alternative biomarker in inflammatory bowel disease.

IF 3.7 2区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Feng-Pai Tsai, Meng-Tzu Weng, Hsin-Yun Wu, Zhi-Che Chen, Chien-Chih Tung, Chun-Ying Wang, Shu-Chen Wei
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引用次数: 0

Abstract

Objectives: Our previous study revealed a correlation between fecal leukocyte esterase and fecal calprotectin levels. This study assessed the predictive value of fecal leukocyte esterase compared with fecal calprotectin and C-reactive protein of inflammatory bowel disease.

Methods: Patients with inflammatory bowel disease who underwent ileocolonoscopy at National Taiwan University Hospital from March 2022 to March 2024 were included. Fecal leukocyte esterase and fecal calprotectin levels from stool samples collected within one month of endoscopy were analyzed. Active ulcerative colitis and Crohn's disease were defined as Mayo endoscopic score ≥2 or simple endoscopic score for Crohn's disease ≥7, respectively. Sensitivity, specificity, predictive values, and areas under the receiver operating characteristic curve were calculated using IBM SPSS Statistics 29.

Results: Of the 203 patients (100 with ulcerative colitis and 103 with Crohn's disease), fecal leukocyte esterase levels were significantly correlated with fecal calprotectin levels (r=0.425, p<0.001) and endoscopic severity in ulcerative colitis (r=0.432, p<0.001) and Crohn's disease (r=0.311, p=0.001). For predicting Mayo endoscopic scores ≥2 in ulcerative colitis using fecal leukocyte esterase, fecal calprotectin, and C-reactive protein, areas under the curve were 0.731, 0.785, and 0.558, respectively. For predicting simple endoscopic scores for Crohn's disease ≥7, areas under the curve were 0.706, 0.800, and 0.770, respectively. No significant difference was observed between fecal leukocyte esterase and fecal calprotectin.

Conclusions: Fecal leukocyte esterase correlates with fecal calprotectin and predicts endoscopic severity in inflammatory bowel disease.

粪便白细胞酯酶水平预测内窥镜严重程度作为炎症性肠病的替代生物标志物。
目的:我们先前的研究揭示了粪便白细胞酯酶和粪便钙保护蛋白水平之间的相关性。本研究评估了粪便白细胞酯酶与粪便钙保护蛋白和c反应蛋白对炎症性肠病的预测价值。方法:纳入2022年3月至2024年3月在台湾大学附属医院行回肠结肠镜检查的炎症性肠病患者。在内镜检查后一个月内收集粪便样本,分析粪便白细胞酯酶和粪钙保护蛋白水平。活动性溃疡性结肠炎和克罗恩病的定义分别为Mayo内镜评分≥2分或克罗恩病单纯内镜评分≥7分。使用IBM SPSS Statistics 29计算灵敏度、特异度、预测值和受试者工作特征曲线下面积。结果:203例患者(溃疡性结肠炎100例,克罗恩病103例)中,粪便白细胞酯酶水平与粪便钙保护蛋白水平显著相关(r=0.425, p)。结论:粪便白细胞酯酶与粪便钙保护蛋白相关,可预测炎症性肠病的内镜严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical chemistry and laboratory medicine
Clinical chemistry and laboratory medicine 医学-医学实验技术
CiteScore
11.30
自引率
16.20%
发文量
306
审稿时长
3 months
期刊介绍: Clinical Chemistry and Laboratory Medicine (CCLM) publishes articles on novel teaching and training methods applicable to laboratory medicine. CCLM welcomes contributions on the progress in fundamental and applied research and cutting-edge clinical laboratory medicine. It is one of the leading journals in the field, with an impact factor over 3. CCLM is issued monthly, and it is published in print and electronically. CCLM is the official journal of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) and publishes regularly EFLM recommendations and news. CCLM is the official journal of the National Societies from Austria (ÖGLMKC); Belgium (RBSLM); Germany (DGKL); Hungary (MLDT); Ireland (ACBI); Italy (SIBioC); Portugal (SPML); and Slovenia (SZKK); and it is affiliated to AACB (Australia) and SFBC (France). Topics: - clinical biochemistry - clinical genomics and molecular biology - clinical haematology and coagulation - clinical immunology and autoimmunity - clinical microbiology - drug monitoring and analysis - evaluation of diagnostic biomarkers - disease-oriented topics (cardiovascular disease, cancer diagnostics, diabetes) - new reagents, instrumentation and technologies - new methodologies - reference materials and methods - reference values and decision limits - quality and safety in laboratory medicine - translational laboratory medicine - clinical metrology Follow @cclm_degruyter on Twitter!
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