Inflammation in Ossification of the Posterior Longitudinal Ligament of the Cervical Spine: Monocytes and Proinflammatory Cytokines Increased Significantly.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Spine Surgery Pub Date : 2025-08-27 DOI:10.1097/BSD.0000000000001929

Hao Wu, Cheng Ye, Longqing Wang, Qing Chen, Dong Xie, Qi Zhao, Mingliang Shi, Baocheng Niu, Lili Yang

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Abstract

Study design: A retrospective cohort study.

Objective: The study aimed to explore the expression difference of inflammatory cells in patients with ossification of the posterior longitudinal ligament (OPLL) of the cervical spine and investigate the expression level of IL-6, IL-1β, MCP-1, TNF-α, RANTES, and IL-10 in patients with OPLL.

Background: Ossification of the posterior longitudinal ligament (OPLL) is a disease that can seriously affect spinal cord and nerve function. Inflammation is thought to be an important source of the pathogenesis of ligament ossification.

Materials and methods: A retrospective study was performed on 215 patients with OPLL and 184 patients without OPLL who were hospitalized in the Spine Surgery Department of Shanghai Changzheng Hospital. A case-control analysis of 147 OPLL patients and 147 demographically matched non-OPLL controls was performed by propensity score matching (PSM) to assess inflammatory cells in peripheral blood. The expression levels of IL-6, IL-1β, MCP-1, TNF-α, RANTES, and IL-10 in the peripheral blood of 53 patients with OPLL and 27 patients without OPLL were determined by the enzyme-linked immunosorbent assay (ELISA) method. The differences between groups were analyzed, and a P-value <0.05 was considered statistically significant.

Results: The peripheral blood monocytes in the OPLL group were significantly higher than those in the control group. The hs-CRP in the mixed type of COPLL group was significantly higher than that of the localized type of OPLL. ELISA showed that the expression levels of IL-1β, TNF-α, and MCP-1 in the peripheral blood of the OPLL group were significantly higher than those of the control group. The expression level of IL-10 in the peripheral blood of the OPLL group was significantly lower than that of the control group.

Conclusion: The expression of monocytes and proinflammatory cytokines in the peripheral blood of OPLL patients was significantly increased, suggesting the existence of inflammation in these patients.

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颈椎后纵韧带骨化炎症：单核细胞和促炎细胞因子显著升高。

研究设计：回顾性队列研究。目的：探讨颈椎后纵韧带骨化（OPLL）患者炎症细胞的表达差异，探讨IL-6、IL-1β、MCP-1、TNF-α、RANTES、IL-10在OPLL患者中的表达水平。背景：后纵韧带骨化症（OPLL）是一种严重影响脊髓和神经功能的疾病。炎症被认为是韧带骨化发病的一个重要原因。材料与方法：对上海长征医院脊柱外科住院的215例OPLL患者和184例无OPLL患者进行回顾性研究。通过倾向评分匹配（PSM）对147例OPLL患者和147例人口统计学匹配的非OPLL对照组进行病例对照分析，以评估外周血中的炎症细胞。采用酶联免疫吸附法（ELISA）检测53例OPLL患者和27例非OPLL患者外周血中IL-6、IL-1β、MCP-1、TNF-α、RANTES和IL-10的表达水平。结果：OPLL组外周血单核细胞明显高于对照组。混合型OPLL组hs-CRP明显高于局限性OPLL组。ELISA检测结果显示，OPLL组外周血IL-1β、TNF-α、MCP-1表达水平显著高于对照组。OPLL组外周血IL-10表达水平明显低于对照组。结论：OPLL患者外周血单核细胞及促炎细胞因子表达明显升高，提示该患者存在炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Spine Surgery Medicine-Surgery

CiteScore

3.00

自引率

5.30%

发文量

236

期刊介绍： Clinical Spine Surgery is the ideal journal for the busy practicing spine surgeon or trainee, as it is the only journal necessary to keep up to date with new clinical research and surgical techniques. Readers get to watch leaders in the field debate controversial topics in a new controversies section, and gain access to evidence-based reviews of important pathologies in the systematic reviews section. The journal features a surgical technique complete with a video, and a tips and tricks section that allows surgeons to review the important steps prior to a complex procedure. Clinical Spine Surgery provides readers with primary research studies, specifically level 1, 2 and 3 studies, ensuring that articles that may actually change a surgeon’s practice will be read and published. Each issue includes a brief article that will help a surgeon better understand the business of healthcare, as well as an article that will help a surgeon understand how to interpret increasingly complex research methodology. Clinical Spine Surgery is your single source for up-to-date, evidence-based recommendations for spine care.