Exploring the role of ferroptosis in esophageal cancer: mechanisms and therapeutic implications.

IF 7 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-08-25 DOI:10.1038/s41420-025-02696-2

Defeng Zhao, Wenze Li, Zhongyu Han, Ziyi Wang, Danni Li, Wenya Li

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Abstract

With the development of medical and health care, esophageal cancer (EC) has become a disease of concern to the scientific research community. At present, among all treatment regimens for EC, surgical resection is conducive to the prognosis of early patients neoadjuvant therapies are recommended for advanced patients. However, treatments now are not satisfactory in suppressing the progression of EC. Ferroptosis is one distinctive cell death mode, noted for the accumulation of iron as well as lipotoxicity, which induce cell membrane to breakdown. As a star protein of ferroptosis related pathway, GPX4 is related to the homeostatic imbalance of tumor immune microenvironment (TIME) of EC, thereby regulating the onset as well as progression of the cancer. In our manuscript, we present the mechanisms involved in ferroptosis, the functions of ferroptosis in the TIME. We also focused on the progression about ferroptosis in EC, as well as targeting ferroptosis-related pathways to delay the development of EC. We expect that these contents can expand fresh insights and aim for EC therapeutic strategy in clinical practice.

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探讨铁下垂在食管癌中的作用：机制和治疗意义。

随着医疗卫生事业的发展，食管癌已成为科学界关注的疾病。目前，在所有治疗方案中，手术切除有利于早期患者的预后，晚期患者建议采用新辅助治疗。然而，目前的治疗方法在抑制EC的进展方面并不令人满意。铁下垂是一种独特的细胞死亡模式，以铁的积累和脂毒性而闻名，其诱导细胞膜破裂。GPX4作为铁凋亡相关通路的明星蛋白，与EC肿瘤免疫微环境（tumor immune microenvironment， TIME）稳态失衡有关，从而调控肿瘤的发生和发展。在我们的手稿中，我们提出了参与铁下垂的机制，铁下垂在时间中的功能。我们也关注了铁下垂在EC中的进展，以及针对铁下垂相关的途径来延缓EC的发展。我们希望这些内容能够拓展新的见解，并为临床实践中的治疗策略提供帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.