Difference Analysis of Brain Functional Activity Between Patients with Residual Dizziness Caused by Benign Paroxysmal Positional Vertigo and Persistent Postural-Perceptual Dizziness: A Resting-State Functional Magnetic Resonance Imaging Study.
Dan Liu, Yang Sun, Cunxin Lin, Shuaishuai Shen, Zhengwei Chen, Yueji Liu, HaiYan Liu, Xiu-E Wei, Lijie Xiao, Liangqun Rong
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引用次数: 0
Abstract
Purpose: To explore brain function differences between patients with residual dizziness (RD) caused by benign paroxysmal positional vertigo (BPPV) and persistent postural-perceptual dizziness (PPPD) with resting-state functional magnetic resonance imaging. Method: Using the Data Processing and Analysis for Brain Imaging software to analyze differences in the amplitude of low-frequency fluctuations (ALFF) and functional connectivity (FC) among RD, PPPD, and healthy controls groups. Then constructed a brain network and compared FC within the network. Further evaluated the correlation between abnormal brain regions and clinical characteristics. Result: (1) Analysis of clinical characteristics: dizziness handicap inventory (DHI) scores differed between RD and PPPD groups. (2) Comparison of ALFF: RD group exhibited increased ALFF values in the right postcentral gyrus, right superior occipital gyrus, and right angular gyrus compared with the PPPD group. (3) Comparison of FC: the PPPD group exhibited weakened FC between the right cerebellum 8 region and right cerebellum crus1 region compared with the RD group. (4) Brain network analysis: Compared with the RD group, the PPPD group exhibited significantly reduced FC between the left supramarginal gyrus and the right angular gyrus. (5) Correlation analysis: The DHI scale scores of PPPD group were positively correlated with ALFF values of the right angular gyrus and negatively correlated with FC values between the right cerebellum 8 region and right cerebellum crus1 region. Conclusions: Significant differences in brain functional activity were observed between RD and PPPD patients, which reveals that there are differences between RD and PPPD patients regarding neural mechanisms in the process of pathogenesis.
期刊介绍：
Brain Connectivity provides groundbreaking findings in the rapidly advancing field of connectivity research at the systems and network levels. The Journal disseminates information on brain mapping, modeling, novel research techniques, new imaging modalities, preclinical animal studies, and the translation of research discoveries from the laboratory to the clinic.
This essential journal fosters the application of basic biological discoveries and contributes to the development of novel diagnostic and therapeutic interventions to recognize and treat a broad range of neurodegenerative and psychiatric disorders such as: Alzheimer’s disease, attention-deficit hyperactivity disorder, posttraumatic stress disorder, epilepsy, traumatic brain injury, stroke, dementia, and depression.
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