{"title":"From Fleas to T Lymphocytes and Beyond: How did I Become an Immunologist, and What Has Resulted from It?","authors":"Paweł Kisielow","doi":"10.2478/aite-2025-0024","DOIUrl":null,"url":null,"abstract":"<p><p>A narrative from a co-author of studies explaining the cellular mechanisms of self/nonself discrimination by the immune system, set against the backdrop of significant advancements in immunology during the last quarter of the 20th century. This review focuses on demonstrating the functional diversity of T cells by identifying their two major subsets: regulatory CD4 and cytotoxic CD8. It also examines the first T-cell receptor (TCR) transgenic mice, providing definitive evidence for both positive and negative selection of immature thymocytes as mechanisms for generating a self-tolerant and MHC-restricted TCR repertoire. The origins of these experiments have been discussed.</p>","PeriodicalId":8389,"journal":{"name":"Archivum Immunologiae et Therapiae Experimentalis","volume":"73 1","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivum Immunologiae et Therapiae Experimentalis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2478/aite-2025-0024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A narrative from a co-author of studies explaining the cellular mechanisms of self/nonself discrimination by the immune system, set against the backdrop of significant advancements in immunology during the last quarter of the 20th century. This review focuses on demonstrating the functional diversity of T cells by identifying their two major subsets: regulatory CD4 and cytotoxic CD8. It also examines the first T-cell receptor (TCR) transgenic mice, providing definitive evidence for both positive and negative selection of immature thymocytes as mechanisms for generating a self-tolerant and MHC-restricted TCR repertoire. The origins of these experiments have been discussed.
期刊介绍:
Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.