Hang Cheong Derek Ng, Christopher Harris, Victoria Stern, Anthony R Hart, Elspeth Helen Whitby
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引用次数: 0
Abstract
Objective: To determine whether full body in-utero MRI (iuMRI) rather than targeted imaging adds useful clinical information when a fetal anomaly is suspected in the brain or the body.
Design: Single-centre retrospective cohort study, from October 2011 to May 2022.
Setting: Regional fetal MRI service in Sheffield, UK.
Patients: All pregnant people undergoing iuMRI.
Interventions: iuMRI of the brain and body was reviewed by a fetal radiologist, and the results discussed by a multidisciplinary team.
Main outcome measures: Additional abnormalities detected on iuMRI outside of the initial area of interest on ultrasound.
Results: 1876 participants: 916 participants had a fetus with brain anomalies only on ultrasound, of which 12 (1.3%) had additional body abnormalities on iuMRI. 960 participants had body anomalies only on ultrasound, of whom 8 (0.8%) had an additional brain abnormality. The additional findings from 12 cases (0.6% of whole cohort) added useful clinical information to guide care or counselling.
Conclusion: If brain or body anomalies are found on ultrasound in the fetus, whole-body iuMRI reveals additional abnormalities in a small number of cases. However, these may provide important information that changes counselling or care. Further research is required to determine how significant this impact is for clinicians and families, whether normal findings reassure families, how long whole-body iuMRI adds to the MRI acquisition time and the health economics implications.
期刊介绍:
Archives of Disease in Childhood is an international peer review journal that aims to keep paediatricians and others up to date with advances in the diagnosis and treatment of childhood diseases as well as advocacy issues such as child protection. It focuses on all aspects of child health and disease from the perinatal period (in the Fetal and Neonatal edition) through to adolescence. ADC includes original research reports, commentaries, reviews of clinical and policy issues, and evidence reports. Areas covered include: community child health, public health, epidemiology, acute paediatrics, advocacy, and ethics.